Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation
The immunologic interaction between the fetus and the mother is a paradoxical communication that is regulated by fetal antigen presentation and/or by recognition of and reaction to these antigens by the maternal immune system. There have been significant advances in understanding of abnormalities in...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/258391 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545785572491264 |
|---|---|
| author | Shyi-Jou Chen Yung-Liang Liu Huey-Kang Sytwu |
| author_facet | Shyi-Jou Chen Yung-Liang Liu Huey-Kang Sytwu |
| author_sort | Shyi-Jou Chen |
| collection | DOAJ |
| description | The immunologic interaction between the fetus and the mother is a paradoxical communication that is regulated by fetal antigen presentation and/or by recognition of and reaction to these antigens by the maternal immune system. There have been significant advances in understanding of abnormalities in the maternal-fetal immunologic relationship in the placental bed that can lead to pregnancy disorders. Moreover, immunologic recognition of pregnancy is vital for the maintenance of gestation, and inadequate recognition of fetal antigens may cause abortion. In this paper, we illustrate the complex immunologic aspects of human reproduction in terms of the role of human leukocyte antigen (HLA), immune cells, cytokines and chemokines, and the balance of immunity in pregnancy. In addition, we review the immunologic processes of human reproduction and the current immunologic therapeutic strategies for pathological disorders of pregnancy. |
| format | Article |
| id | doaj-art-61db332ef66f475f84234e0b37ad3b95 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-61db332ef66f475f84234e0b37ad3b952025-02-03T07:24:41ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/258391258391Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for ImmunomodulationShyi-Jou Chen0Yung-Liang Liu1Huey-Kang Sytwu2Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanDepartment of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanDepartment of Microbiology and Immunology, National Defense Medical Center, Taipei 114, TaiwanThe immunologic interaction between the fetus and the mother is a paradoxical communication that is regulated by fetal antigen presentation and/or by recognition of and reaction to these antigens by the maternal immune system. There have been significant advances in understanding of abnormalities in the maternal-fetal immunologic relationship in the placental bed that can lead to pregnancy disorders. Moreover, immunologic recognition of pregnancy is vital for the maintenance of gestation, and inadequate recognition of fetal antigens may cause abortion. In this paper, we illustrate the complex immunologic aspects of human reproduction in terms of the role of human leukocyte antigen (HLA), immune cells, cytokines and chemokines, and the balance of immunity in pregnancy. In addition, we review the immunologic processes of human reproduction and the current immunologic therapeutic strategies for pathological disorders of pregnancy.http://dx.doi.org/10.1155/2012/258391 |
| spellingShingle | Shyi-Jou Chen Yung-Liang Liu Huey-Kang Sytwu Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation Clinical and Developmental Immunology |
| title | Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation |
| title_full | Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation |
| title_fullStr | Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation |
| title_full_unstemmed | Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation |
| title_short | Immunologic Regulation in Pregnancy: From Mechanism to Therapeutic Strategy for Immunomodulation |
| title_sort | immunologic regulation in pregnancy from mechanism to therapeutic strategy for immunomodulation |
| url | http://dx.doi.org/10.1155/2012/258391 |
| work_keys_str_mv | AT shyijouchen immunologicregulationinpregnancyfrommechanismtotherapeuticstrategyforimmunomodulation AT yungliangliu immunologicregulationinpregnancyfrommechanismtotherapeuticstrategyforimmunomodulation AT hueykangsytwu immunologicregulationinpregnancyfrommechanismtotherapeuticstrategyforimmunomodulation |