Preoperative CT-based radiomics nomogram for progression-free survival prediction in pediatric posterior mediastinal malignancies
BackgroundProgression-free survival (PFS) prediction plays a pivotal role in developing personalized treatment strategies and ensuring favorable long-term outcomes in pediatric posterior mediastinal malignant tumors. This study developed and validated the first preoperative contrast-enhanced compute...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1586980/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850185630631329792 |
|---|---|
| author | Shucheng Bi Chenghao Chen Jie Yu Ting Yang Jihang Sun Zunying Hu Qi Zeng Yun Peng |
| author_facet | Shucheng Bi Chenghao Chen Jie Yu Ting Yang Jihang Sun Zunying Hu Qi Zeng Yun Peng |
| author_sort | Shucheng Bi |
| collection | DOAJ |
| description | BackgroundProgression-free survival (PFS) prediction plays a pivotal role in developing personalized treatment strategies and ensuring favorable long-term outcomes in pediatric posterior mediastinal malignant tumors. This study developed and validated the first preoperative contrast-enhanced computed tomography (CT)-based radiomics nomogram to forecast PFS in posterior mediastinal malignancies patients. The aim was to provide a clinically applicable prognostic tool to stratify high-risk populations.MethodsMedical data from 306 patients with posterior mediastinal malignancies were analyzed retrospectively and randomly divided into training (n = 215) and test sets (n = 91). The clinical model was built using conventional clinical data and CT signs. Selection of the radiomic features was performed using maximum relevance minimum redundancy and the least absolute shrinkage and selection operator. To overcome class imbalance, the synthetic minority over-sampling technique was used in the training set. Radiomics signature was derived using logistic regression algorithm, and we developed a nomogram by integrating the clinical model and the radiomics signature. The predictive efficiency of the nomogram was assessed using the area under the curve (AUC), brier score (BS), decision curve analysis, and calibration.ResultsThe Ki-67 index and metastasis were identified as independent predictors, with the test set achieving an AUC of 0.82 (0.647–0.964) and a BS of 0.21 (0.181–0.239). Nineteen radiomics features most relevant to PFS were retained, with the logistic regression algorithm achieving an AUC of 0.77 (0.589–0.896) and a BS of 0.26 (0.215–0.292) in the test set. The radiomics nomogram demonstrated best predictive capability in the test set, achieving an AUC of 0.87 (0.733–0.968) and a BS of 0.22 (0.177–0.255), compared with remaining prediction models. Both calibration curves and decision curve analysis demonstrated good fit and clinical benefit.ConclusionsOur contrast-enhanced CT-based radiomics nomogram may be a dependable, precise, and noninvasive prognostic tool to predict PFS in pediatric posterior mediastinal malignancies preoperatively. |
| format | Article |
| id | doaj-art-61d2f62fee11497e8d0397501b4ef5df |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-61d2f62fee11497e8d0397501b4ef5df2025-08-20T02:16:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.15869801586980Preoperative CT-based radiomics nomogram for progression-free survival prediction in pediatric posterior mediastinal malignanciesShucheng Bi0Chenghao Chen1Jie Yu2Ting Yang3Jihang Sun4Zunying Hu5Qi Zeng6Yun Peng7Department of Radiology, Ministry of Education (MOE) Key Laboratory of Major Diseases in Children, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Thoracic Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Thoracic Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Thoracic Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Radiology, Ministry of Education (MOE) Key Laboratory of Major Diseases in Children, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Radiology, Ministry of Education (MOE) Key Laboratory of Major Diseases in Children, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Thoracic Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Radiology, Ministry of Education (MOE) Key Laboratory of Major Diseases in Children, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaBackgroundProgression-free survival (PFS) prediction plays a pivotal role in developing personalized treatment strategies and ensuring favorable long-term outcomes in pediatric posterior mediastinal malignant tumors. This study developed and validated the first preoperative contrast-enhanced computed tomography (CT)-based radiomics nomogram to forecast PFS in posterior mediastinal malignancies patients. The aim was to provide a clinically applicable prognostic tool to stratify high-risk populations.MethodsMedical data from 306 patients with posterior mediastinal malignancies were analyzed retrospectively and randomly divided into training (n = 215) and test sets (n = 91). The clinical model was built using conventional clinical data and CT signs. Selection of the radiomic features was performed using maximum relevance minimum redundancy and the least absolute shrinkage and selection operator. To overcome class imbalance, the synthetic minority over-sampling technique was used in the training set. Radiomics signature was derived using logistic regression algorithm, and we developed a nomogram by integrating the clinical model and the radiomics signature. The predictive efficiency of the nomogram was assessed using the area under the curve (AUC), brier score (BS), decision curve analysis, and calibration.ResultsThe Ki-67 index and metastasis were identified as independent predictors, with the test set achieving an AUC of 0.82 (0.647–0.964) and a BS of 0.21 (0.181–0.239). Nineteen radiomics features most relevant to PFS were retained, with the logistic regression algorithm achieving an AUC of 0.77 (0.589–0.896) and a BS of 0.26 (0.215–0.292) in the test set. The radiomics nomogram demonstrated best predictive capability in the test set, achieving an AUC of 0.87 (0.733–0.968) and a BS of 0.22 (0.177–0.255), compared with remaining prediction models. Both calibration curves and decision curve analysis demonstrated good fit and clinical benefit.ConclusionsOur contrast-enhanced CT-based radiomics nomogram may be a dependable, precise, and noninvasive prognostic tool to predict PFS in pediatric posterior mediastinal malignancies preoperatively.https://www.frontiersin.org/articles/10.3389/fonc.2025.1586980/fullpediatricmediastinalmalignantradiomicsprogression-free survivalCT |
| spellingShingle | Shucheng Bi Chenghao Chen Jie Yu Ting Yang Jihang Sun Zunying Hu Qi Zeng Yun Peng Preoperative CT-based radiomics nomogram for progression-free survival prediction in pediatric posterior mediastinal malignancies Frontiers in Oncology pediatric mediastinal malignant radiomics progression-free survival CT |
| title | Preoperative CT-based radiomics nomogram for progression-free survival prediction in pediatric posterior mediastinal malignancies |
| title_full | Preoperative CT-based radiomics nomogram for progression-free survival prediction in pediatric posterior mediastinal malignancies |
| title_fullStr | Preoperative CT-based radiomics nomogram for progression-free survival prediction in pediatric posterior mediastinal malignancies |
| title_full_unstemmed | Preoperative CT-based radiomics nomogram for progression-free survival prediction in pediatric posterior mediastinal malignancies |
| title_short | Preoperative CT-based radiomics nomogram for progression-free survival prediction in pediatric posterior mediastinal malignancies |
| title_sort | preoperative ct based radiomics nomogram for progression free survival prediction in pediatric posterior mediastinal malignancies |
| topic | pediatric mediastinal malignant radiomics progression-free survival CT |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1586980/full |
| work_keys_str_mv | AT shuchengbi preoperativectbasedradiomicsnomogramforprogressionfreesurvivalpredictioninpediatricposteriormediastinalmalignancies AT chenghaochen preoperativectbasedradiomicsnomogramforprogressionfreesurvivalpredictioninpediatricposteriormediastinalmalignancies AT jieyu preoperativectbasedradiomicsnomogramforprogressionfreesurvivalpredictioninpediatricposteriormediastinalmalignancies AT tingyang preoperativectbasedradiomicsnomogramforprogressionfreesurvivalpredictioninpediatricposteriormediastinalmalignancies AT jihangsun preoperativectbasedradiomicsnomogramforprogressionfreesurvivalpredictioninpediatricposteriormediastinalmalignancies AT zunyinghu preoperativectbasedradiomicsnomogramforprogressionfreesurvivalpredictioninpediatricposteriormediastinalmalignancies AT qizeng preoperativectbasedradiomicsnomogramforprogressionfreesurvivalpredictioninpediatricposteriormediastinalmalignancies AT yunpeng preoperativectbasedradiomicsnomogramforprogressionfreesurvivalpredictioninpediatricposteriormediastinalmalignancies |