Automatic measurement of choroidal thickness with swept-source optical coherence tomography in chronic Vogt-Koyanagi-Harada disease: 3 years’ follow-up
Abstract Purpose The course of Vogt-Koyanagi-Harada (VKH) disease is typically assessed qualitatively using indocyanine green angiography (ICGA) and enhanced-depth imaging optical coherence tomography (EDI-OCT). However, a quantitative approach could improve accuracy and objectivity. The aim of this...
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SpringerOpen
2024-12-01
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| Series: | Journal of Ophthalmic Inflammation and Infection |
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| Online Access: | https://doi.org/10.1186/s12348-024-00445-7 |
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| author | Liria Yamamoto-Rodríguez Alexander Anduaga-Beramendi Roger Mediavilla-Vallespín Olaia Subirà Pere Garcia-Bru Xavier Solanich-Moreno Luis Arias Josep M. Caminal Olga García-García |
| author_facet | Liria Yamamoto-Rodríguez Alexander Anduaga-Beramendi Roger Mediavilla-Vallespín Olaia Subirà Pere Garcia-Bru Xavier Solanich-Moreno Luis Arias Josep M. Caminal Olga García-García |
| author_sort | Liria Yamamoto-Rodríguez |
| collection | DOAJ |
| description | Abstract Purpose The course of Vogt-Koyanagi-Harada (VKH) disease is typically assessed qualitatively using indocyanine green angiography (ICGA) and enhanced-depth imaging optical coherence tomography (EDI-OCT). However, a quantitative approach could improve accuracy and objectivity. The aim of this study was to assess the clinical value of the automated measurement capabilities of swept-source optical coherence tomography (SS-OCT) to measure choroidal thickness (quantitative approach) in chronic VKH. Methods Prospective, longitudinal case–control study at a tertiary university hospital involving 23 chronic VKH patients (9 convalescent and 14 quiescent) and 17 age-matched controls. Choroidal thickness was automatically measured with SS-OCT. Results Choroidal thinning and improved vision were associated with treatment while increasing thickness and worsening vision were associated with posterior relapse. Overall, 41.6% of asymptomatic (no change in visual acuity) recurrences in the convalescent group and 25% of recurrences in the quiescent group were detected by SS-OCT. All recurrences diagnosed by SS-OCT showed signs of inflammation on ICGA. Conclusions Automatic measurement of choroidal thickness with SS-OCT is a rapid, non-invasive method of detecting posterior segment recurrences and treatment response in VKH patients, and could reduce the need for angiography to monitor this disease. |
| format | Article |
| id | doaj-art-61cbe959ddbf432596e40e36dd2f4076 |
| institution | Kabale University |
| issn | 1869-5760 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Ophthalmic Inflammation and Infection |
| spelling | doaj-art-61cbe959ddbf432596e40e36dd2f40762024-12-08T12:40:55ZengSpringerOpenJournal of Ophthalmic Inflammation and Infection1869-57602024-12-0114111310.1186/s12348-024-00445-7Automatic measurement of choroidal thickness with swept-source optical coherence tomography in chronic Vogt-Koyanagi-Harada disease: 3 years’ follow-upLiria Yamamoto-Rodríguez0Alexander Anduaga-Beramendi1Roger Mediavilla-Vallespín2Olaia Subirà3Pere Garcia-Bru4Xavier Solanich-Moreno5Luis Arias6Josep M. Caminal7Olga García-García8Ophthalmology Department, University Hospital of Bellvitge, Hospitalet de LlobregatOphthalmology Department, University Hospital of Bellvitge, Hospitalet de LlobregatOphthalmology Department, University Hospital of Bellvitge, Hospitalet de LlobregatOphthalmology Department, University Hospital of Bellvitge, Hospitalet de LlobregatOphthalmology Department, University Hospital of Bellvitge, Hospitalet de LlobregatInternal Medicine Department, University Hospital of Bellvitge, Hospitalet de LlobregatOphthalmology Department, University Hospital of Bellvitge, Hospitalet de LlobregatOphthalmology Department, University Hospital of Bellvitge, Hospitalet de LlobregatOphthalmology Department, University Hospital of Bellvitge, Hospitalet de LlobregatAbstract Purpose The course of Vogt-Koyanagi-Harada (VKH) disease is typically assessed qualitatively using indocyanine green angiography (ICGA) and enhanced-depth imaging optical coherence tomography (EDI-OCT). However, a quantitative approach could improve accuracy and objectivity. The aim of this study was to assess the clinical value of the automated measurement capabilities of swept-source optical coherence tomography (SS-OCT) to measure choroidal thickness (quantitative approach) in chronic VKH. Methods Prospective, longitudinal case–control study at a tertiary university hospital involving 23 chronic VKH patients (9 convalescent and 14 quiescent) and 17 age-matched controls. Choroidal thickness was automatically measured with SS-OCT. Results Choroidal thinning and improved vision were associated with treatment while increasing thickness and worsening vision were associated with posterior relapse. Overall, 41.6% of asymptomatic (no change in visual acuity) recurrences in the convalescent group and 25% of recurrences in the quiescent group were detected by SS-OCT. All recurrences diagnosed by SS-OCT showed signs of inflammation on ICGA. Conclusions Automatic measurement of choroidal thickness with SS-OCT is a rapid, non-invasive method of detecting posterior segment recurrences and treatment response in VKH patients, and could reduce the need for angiography to monitor this disease.https://doi.org/10.1186/s12348-024-00445-7Swept-source-OCTVogt-Koyanagi-HaradaChoroidThicknessChronicRelapses |
| spellingShingle | Liria Yamamoto-Rodríguez Alexander Anduaga-Beramendi Roger Mediavilla-Vallespín Olaia Subirà Pere Garcia-Bru Xavier Solanich-Moreno Luis Arias Josep M. Caminal Olga García-García Automatic measurement of choroidal thickness with swept-source optical coherence tomography in chronic Vogt-Koyanagi-Harada disease: 3 years’ follow-up Journal of Ophthalmic Inflammation and Infection Swept-source-OCT Vogt-Koyanagi-Harada Choroid Thickness Chronic Relapses |
| title | Automatic measurement of choroidal thickness with swept-source optical coherence tomography in chronic Vogt-Koyanagi-Harada disease: 3 years’ follow-up |
| title_full | Automatic measurement of choroidal thickness with swept-source optical coherence tomography in chronic Vogt-Koyanagi-Harada disease: 3 years’ follow-up |
| title_fullStr | Automatic measurement of choroidal thickness with swept-source optical coherence tomography in chronic Vogt-Koyanagi-Harada disease: 3 years’ follow-up |
| title_full_unstemmed | Automatic measurement of choroidal thickness with swept-source optical coherence tomography in chronic Vogt-Koyanagi-Harada disease: 3 years’ follow-up |
| title_short | Automatic measurement of choroidal thickness with swept-source optical coherence tomography in chronic Vogt-Koyanagi-Harada disease: 3 years’ follow-up |
| title_sort | automatic measurement of choroidal thickness with swept source optical coherence tomography in chronic vogt koyanagi harada disease 3 years follow up |
| topic | Swept-source-OCT Vogt-Koyanagi-Harada Choroid Thickness Chronic Relapses |
| url | https://doi.org/10.1186/s12348-024-00445-7 |
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