A case report of anal fistula-associated mucinous adenocarcinoma developing 3 years after treatment of perianal abscess
Abstract Background A long-standing (over 10 years) anal fistula is considered a fundamental cause of fistula-associated mucinous adenocarcinoma (FAMC). Perianal abscesses and anal fistulas are two sequential phases of the same anorectal infectious process. We experienced a case of FAMC which develo...
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Japan Surgical Society
2023-09-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-023-01743-3 |
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| author | Michihiro Koizumi Akihisa Matsuda Takeshi Yamada Koji Morimoto Itaru Kubota Yawara Kubota Shuzo Tamura Kenta Tominaga Takashi Sakatani Hiroshi Yoshida |
| author_facet | Michihiro Koizumi Akihisa Matsuda Takeshi Yamada Koji Morimoto Itaru Kubota Yawara Kubota Shuzo Tamura Kenta Tominaga Takashi Sakatani Hiroshi Yoshida |
| author_sort | Michihiro Koizumi |
| collection | DOAJ |
| description | Abstract Background A long-standing (over 10 years) anal fistula is considered a fundamental cause of fistula-associated mucinous adenocarcinoma (FAMC). Perianal abscesses and anal fistulas are two sequential phases of the same anorectal infectious process. We experienced a case of FAMC which developed 3 years after the treatment of a perianal abscess. Case presentation A 68-year-old woman was admitted to our hospital because of progressive anal pain and a palpable tumor. She had a history of undergoing a drainage operation for a perianal abscess 3 years previously. A 15 × 15-mm tumor at the former drainage site was identified; transanal ultrasonography showed an intersphincteric fistula connecting to the tumor. A biopsy taken from the tumor demonstrated mucinous adenocarcinoma; the tumor was diagnosed as FAMC. Laparoscopic abdominoperineal resection was performed. Histopathology showed highly dysplastic cells lining the lumen of the anal fistula and poorly differentiated mucinous adenocarcinoma proliferating in the dermis and epidermis in the distal aspect of the fistula. Conclusions FAMC can develop within fewer than 3 years after the development of a perianal abscess and anal fistula. |
| format | Article |
| id | doaj-art-61c27de32bf0425d9fe0bd77969e30bd |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-61c27de32bf0425d9fe0bd77969e30bd2025-08-20T03:33:13ZengJapan Surgical SocietySurgical Case Reports2198-77932023-09-01911510.1186/s40792-023-01743-3A case report of anal fistula-associated mucinous adenocarcinoma developing 3 years after treatment of perianal abscessMichihiro Koizumi0Akihisa Matsuda1Takeshi Yamada2Koji Morimoto3Itaru Kubota4Yawara Kubota5Shuzo Tamura6Kenta Tominaga7Takashi Sakatani8Hiroshi Yoshida9Nishiarai Coloproctology ClinicDepartment of Gastrointestinal and Hepato‐Biliary‐Pancreatic Surgery, Nippon Medical SchoolDepartment of Gastrointestinal and Hepato‐Biliary‐Pancreatic Surgery, Nippon Medical SchoolNishiarai Coloproctology ClinicNishiarai Coloproctology ClinicNishiarai Coloproctology ClinicNishiarai Coloproctology ClinicDepartment of Diagnostic Pathology, Nippon Medical SchoolDepartment of Diagnostic Pathology, Nippon Medical SchoolDepartment of Gastrointestinal and Hepato‐Biliary‐Pancreatic Surgery, Nippon Medical SchoolAbstract Background A long-standing (over 10 years) anal fistula is considered a fundamental cause of fistula-associated mucinous adenocarcinoma (FAMC). Perianal abscesses and anal fistulas are two sequential phases of the same anorectal infectious process. We experienced a case of FAMC which developed 3 years after the treatment of a perianal abscess. Case presentation A 68-year-old woman was admitted to our hospital because of progressive anal pain and a palpable tumor. She had a history of undergoing a drainage operation for a perianal abscess 3 years previously. A 15 × 15-mm tumor at the former drainage site was identified; transanal ultrasonography showed an intersphincteric fistula connecting to the tumor. A biopsy taken from the tumor demonstrated mucinous adenocarcinoma; the tumor was diagnosed as FAMC. Laparoscopic abdominoperineal resection was performed. Histopathology showed highly dysplastic cells lining the lumen of the anal fistula and poorly differentiated mucinous adenocarcinoma proliferating in the dermis and epidermis in the distal aspect of the fistula. Conclusions FAMC can develop within fewer than 3 years after the development of a perianal abscess and anal fistula.https://doi.org/10.1186/s40792-023-01743-3Fistula-associated mucinous adenocarcinomaAnal carcinomaAnal fistulaPerianal abscessCryptitisCryptoglandular infectious theory |
| spellingShingle | Michihiro Koizumi Akihisa Matsuda Takeshi Yamada Koji Morimoto Itaru Kubota Yawara Kubota Shuzo Tamura Kenta Tominaga Takashi Sakatani Hiroshi Yoshida A case report of anal fistula-associated mucinous adenocarcinoma developing 3 years after treatment of perianal abscess Surgical Case Reports Fistula-associated mucinous adenocarcinoma Anal carcinoma Anal fistula Perianal abscess Cryptitis Cryptoglandular infectious theory |
| title | A case report of anal fistula-associated mucinous adenocarcinoma developing 3 years after treatment of perianal abscess |
| title_full | A case report of anal fistula-associated mucinous adenocarcinoma developing 3 years after treatment of perianal abscess |
| title_fullStr | A case report of anal fistula-associated mucinous adenocarcinoma developing 3 years after treatment of perianal abscess |
| title_full_unstemmed | A case report of anal fistula-associated mucinous adenocarcinoma developing 3 years after treatment of perianal abscess |
| title_short | A case report of anal fistula-associated mucinous adenocarcinoma developing 3 years after treatment of perianal abscess |
| title_sort | case report of anal fistula associated mucinous adenocarcinoma developing 3 years after treatment of perianal abscess |
| topic | Fistula-associated mucinous adenocarcinoma Anal carcinoma Anal fistula Perianal abscess Cryptitis Cryptoglandular infectious theory |
| url | https://doi.org/10.1186/s40792-023-01743-3 |
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