Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts.
Discontinuation of tyrosine kinase inhibitors (TKI) is the main goal today in the field of Philadelphia positive chronic myeloid leukemia (Ph + CML) and the criteria to attempt the interruption of therapy are well defined and rely on the possibility to regularly monitor the BCR-ABL1 transcript. Pati...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2020-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Online Access: | https://www.mjhid.org/index.php/mjhid/article/view/4306 |
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| author | Matteo Dragani Jessica Petiti Giovanna Rege-Cambrin Enrico Gottardi Filomena Daraio Giovanni Caocci Chiara Aguzzi Elena Crisà Giacomo Andreani Francesca Caciolli Carmen Fava |
| author_facet | Matteo Dragani Jessica Petiti Giovanna Rege-Cambrin Enrico Gottardi Filomena Daraio Giovanni Caocci Chiara Aguzzi Elena Crisà Giacomo Andreani Francesca Caciolli Carmen Fava |
| author_sort | Matteo Dragani |
| collection | DOAJ |
| description | Discontinuation of tyrosine kinase inhibitors (TKI) is the main goal today in the field of Philadelphia positive chronic myeloid leukemia (Ph + CML) and the criteria to attempt the interruption of therapy are well defined and rely on the possibility to regularly monitor the BCR-ABL1 transcript. Patients harboring atypical transcripts are automatically excluded from protocols due to the absence of a standardized method of quantification of their minimal residual disease (MRD). We report here the outcome of 6 patients with atypical transcripts with a long follow up whose MRD was followed in three cases with digital PCR during their treatment free remission (TFR). |
| format | Article |
| id | doaj-art-61bfd387faee476c97d0c65d9db95968 |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-61bfd387faee476c97d0c65d9db959682025-08-20T02:08:35ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062020-08-0112110.4084/mjhid.2020.066Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts.Matteo Dragani0Jessica Petiti1Giovanna Rege-Cambrin2Enrico Gottardi3Filomena Daraio4Giovanni Caocci5Chiara Aguzzi6Elena Crisà7Giacomo Andreani8Francesca Caciolli9Carmen Fava10{'en_US': 'Department of Clinical and Biological Sciences, University of Turin, Orbassano'}Department of Clinical and Biological Sciences, University of Turin, OrbassanoDepartment of Clinical and Biological Sciences, University of Turin, OrbassanoDepartment of Clinical and Biological Sciences, University of Turin, OrbassanoDepartment of Clinical and Biological Sciences, University of Turin, OrbassanoDepartment of Hematology, University of Cagliari, CagliariDepartment of Biotechnologies and Hematology, University of Turin, TurinDepartment of Hematology, University of Oriental Piedmont, NovaraDepartment of Clinical and Biological Sciences, University of Turin, OrbassanoDepartment of Clinical and Biological Sciences, University of Turin, OrbassanoDepartment of Clinical and Biological Sciences, University of Turin, OrbassanoDiscontinuation of tyrosine kinase inhibitors (TKI) is the main goal today in the field of Philadelphia positive chronic myeloid leukemia (Ph + CML) and the criteria to attempt the interruption of therapy are well defined and rely on the possibility to regularly monitor the BCR-ABL1 transcript. Patients harboring atypical transcripts are automatically excluded from protocols due to the absence of a standardized method of quantification of their minimal residual disease (MRD). We report here the outcome of 6 patients with atypical transcripts with a long follow up whose MRD was followed in three cases with digital PCR during their treatment free remission (TFR).https://www.mjhid.org/index.php/mjhid/article/view/4306 |
| spellingShingle | Matteo Dragani Jessica Petiti Giovanna Rege-Cambrin Enrico Gottardi Filomena Daraio Giovanni Caocci Chiara Aguzzi Elena Crisà Giacomo Andreani Francesca Caciolli Carmen Fava Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts. Mediterranean Journal of Hematology and Infectious Diseases |
| title | Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts. |
| title_full | Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts. |
| title_fullStr | Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts. |
| title_full_unstemmed | Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts. |
| title_short | Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts. |
| title_sort | treatment free remission in chronic myeloid leukemia harboring atypical bcr abl1 transcripts |
| url | https://www.mjhid.org/index.php/mjhid/article/view/4306 |
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