The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse

The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse

Abstract Endosomal nucleic acid sensing by Toll-like receptors (TLRs) is central to antimicrobial immunity and several autoimmune conditions such as systemic lupus erythematosus (SLE). The innate immune adaptor TASL mediates, via the interaction with SLC15A4, the activation of IRF5 downstream of hum...

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Main Authors: Ales Drobek, Léa Bernaleau, Maeva Delacrétaz, Sandra Calderon Copete, Claire Royer-Chardon, Mélissa Longepierre, Marta Monguió-Tortajada, Jakub Korzeniowski, Samuel Rotman, Julien Marquis, Manuele Rebsamen
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55692-y
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