POLYMYXIN-SEWN HEMOSORBENT FOR THE TREATMENT OF PATIENTS WITH SEPTIC SHOCK
ABSTRACT. The key component of the sepsis pathogenesis is the gram-negative bacteria endotoxin. It is a lipopolysaccharide of the bacterial wall, which circulation in the bloodstream results in unlimited activation of some biological systems, causing serious complications. Nowadays, there are develo...
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| Format: | Article |
| Language: | Russian |
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2016-03-01
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| Series: | Неотложная медицинская помощь |
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| Online Access: | https://www.jnmp.ru/jour/article/view/250 |
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| author | V. V. Kirkovsky I. G. Kolesnikova D. S. Tretyak E. L. Sedjolkina |
| author_facet | V. V. Kirkovsky I. G. Kolesnikova D. S. Tretyak E. L. Sedjolkina |
| author_sort | V. V. Kirkovsky |
| collection | DOAJ |
| description | ABSTRACT. The key component of the sepsis pathogenesis is the gram-negative bacteria endotoxin. It is a lipopolysaccharide of the bacterial wall, which circulation in the bloodstream results in unlimited activation of some biological systems, causing serious complications. Nowadays, there are developed and practiced sorption methods, based on the selective removal of the lipopolysaccharide from the blood during perfusion through the sorption column with covalently immobilized polymyxin on a bioinert matrix, which can bind and inactivate it. The therapeutic effect of hemosorption using the biospecific antilipopolysaccharide hemosorbent has been studied in patients with septic shock, associated with peritonitis and septic complications of destructive pancreatitis. |
| format | Article |
| id | doaj-art-61bc1ae7dcda433099a5350daaa015e8 |
| institution | DOAJ |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| publishDate | 2016-03-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj-art-61bc1ae7dcda433099a5350daaa015e82025-08-20T03:18:31ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172016-03-01042226246POLYMYXIN-SEWN HEMOSORBENT FOR THE TREATMENT OF PATIENTS WITH SEPTIC SHOCKV. V. Kirkovsky0I. G. Kolesnikova1D. S. Tretyak2E. L. Sedjolkina3Belarusian State Medical university, MinskBelarusian State Medical university, MinskBelarusian State Medical university, MinskBelarusian State Medical university, MinskABSTRACT. The key component of the sepsis pathogenesis is the gram-negative bacteria endotoxin. It is a lipopolysaccharide of the bacterial wall, which circulation in the bloodstream results in unlimited activation of some biological systems, causing serious complications. Nowadays, there are developed and practiced sorption methods, based on the selective removal of the lipopolysaccharide from the blood during perfusion through the sorption column with covalently immobilized polymyxin on a bioinert matrix, which can bind and inactivate it. The therapeutic effect of hemosorption using the biospecific antilipopolysaccharide hemosorbent has been studied in patients with septic shock, associated with peritonitis and septic complications of destructive pancreatitis.https://www.jnmp.ru/jour/article/view/250hemosorbentdetoxificationpolymyxinendotoxinlipopolysaccharidesepsis |
| spellingShingle | V. V. Kirkovsky I. G. Kolesnikova D. S. Tretyak E. L. Sedjolkina POLYMYXIN-SEWN HEMOSORBENT FOR THE TREATMENT OF PATIENTS WITH SEPTIC SHOCK Неотложная медицинская помощь hemosorbent detoxification polymyxin endotoxin lipopolysaccharide sepsis |
| title | POLYMYXIN-SEWN HEMOSORBENT FOR THE TREATMENT OF PATIENTS WITH SEPTIC SHOCK |
| title_full | POLYMYXIN-SEWN HEMOSORBENT FOR THE TREATMENT OF PATIENTS WITH SEPTIC SHOCK |
| title_fullStr | POLYMYXIN-SEWN HEMOSORBENT FOR THE TREATMENT OF PATIENTS WITH SEPTIC SHOCK |
| title_full_unstemmed | POLYMYXIN-SEWN HEMOSORBENT FOR THE TREATMENT OF PATIENTS WITH SEPTIC SHOCK |
| title_short | POLYMYXIN-SEWN HEMOSORBENT FOR THE TREATMENT OF PATIENTS WITH SEPTIC SHOCK |
| title_sort | polymyxin sewn hemosorbent for the treatment of patients with septic shock |
| topic | hemosorbent detoxification polymyxin endotoxin lipopolysaccharide sepsis |
| url | https://www.jnmp.ru/jour/article/view/250 |
| work_keys_str_mv | AT vvkirkovsky polymyxinsewnhemosorbentforthetreatmentofpatientswithsepticshock AT igkolesnikova polymyxinsewnhemosorbentforthetreatmentofpatientswithsepticshock AT dstretyak polymyxinsewnhemosorbentforthetreatmentofpatientswithsepticshock AT elsedjolkina polymyxinsewnhemosorbentforthetreatmentofpatientswithsepticshock |