Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives
Providing tuberculosis preventive treatment (TPT) to close contacts of persons with TB is a core strategy recommended by WHO for the prevention and control of TB. Nigeria rolled out the 3-month Isoniazid-Rifampicin (3HR) shorter regimen TPT as a pilot for use among eligible adult and child contacts....
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MDPI AG
2024-12-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/9/12/301 |
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| author | Austin Ihesie Ogoamaka Chukwuogo Rupert Eneogu Olugbenga Kayode Daniel Aderonke Agbaje Bethrand Odume Debby Nongo Charles Ohikhuai Nera Kadiri-Eneh Omosalewa Oyelaran Victor Obianeri Wayne Van Gemert Enos Okumu Masini Cleophas D’auvergne Urhioke Ochuko Chukwuma Anyaike Sunday Olakunle Olarewaju |
| author_facet | Austin Ihesie Ogoamaka Chukwuogo Rupert Eneogu Olugbenga Kayode Daniel Aderonke Agbaje Bethrand Odume Debby Nongo Charles Ohikhuai Nera Kadiri-Eneh Omosalewa Oyelaran Victor Obianeri Wayne Van Gemert Enos Okumu Masini Cleophas D’auvergne Urhioke Ochuko Chukwuma Anyaike Sunday Olakunle Olarewaju |
| author_sort | Austin Ihesie |
| collection | DOAJ |
| description | Providing tuberculosis preventive treatment (TPT) to close contacts of persons with TB is a core strategy recommended by WHO for the prevention and control of TB. Nigeria rolled out the 3-month Isoniazid-Rifampicin (3HR) shorter regimen TPT as a pilot for use among eligible adult and child contacts. This study assesses acceptance and completion rates of 3HR TPT among contacts and determines the perspectives of healthcare workers (HCWs) and contacts on acceptance and completion of 3HR TPT in Nigeria. In this cross-sectional descriptive study using mixed methods, records of TPT-eligible clients were retrospectively reviewed, while 18 purposely selected HCWs and 18 contacts on 3HR were interviewed. Of the 30,012 eligible contacts, 12,040 (40.1%) were initiated on TPT. Among these, 8213 (68%) were enrolled on 3HR, and 6972 (84.7%) of them completed treatment. Perceived facilitators include belief in its effectiveness, training among HCWs, and a good understanding of TPT from HCW counseling sessions. Barriers reported were linked to stockouts, misconceptions about side effects, non-disclosures, and disincentive follow-up strategies. The acceptance and completion rate for 3HR TPT was good. Scaling up 3HR TPT will require redesigning policies towards addressing identified barriers and utilizing interventions linked to capabilities, opportunities, and motivations among contacts of TB patients and HCWs. |
| format | Article |
| id | doaj-art-61bb939cdf6746438895da20475016c2 |
| institution | DOAJ |
| issn | 2414-6366 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Tropical Medicine and Infectious Disease |
| spelling | doaj-art-61bb939cdf6746438895da20475016c22025-08-20T02:43:54ZengMDPI AGTropical Medicine and Infectious Disease2414-63662024-12-0191230110.3390/tropicalmed9120301Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ PerspectivesAustin Ihesie0Ogoamaka Chukwuogo1Rupert Eneogu2Olugbenga Kayode Daniel3Aderonke Agbaje4Bethrand Odume5Debby Nongo6Charles Ohikhuai7Nera Kadiri-Eneh8Omosalewa Oyelaran9Victor Obianeri10Wayne Van Gemert11Enos Okumu Masini12Cleophas D’auvergne13Urhioke Ochuko14Chukwuma Anyaike15Sunday Olakunle Olarewaju16United States Agency for International Development, Central Business District, Abuja 900211, NigeriaKNCV Nigeria, Central Business District, Abuja 900211, NigeriaUnited States Agency for International Development, Central Business District, Abuja 900211, NigeriaInstitute of Human Virology Nigeria (IHVN), IHVN Towers, C00 Emeritus Umaru Shehu Ave, Cadastral, Abuja 900108, NigeriaInstitute of Human Virology Nigeria (IHVN), IHVN Towers, C00 Emeritus Umaru Shehu Ave, Cadastral, Abuja 900108, NigeriaKNCV Nigeria, Central Business District, Abuja 900211, NigeriaUnited States Agency for International Development, Central Business District, Abuja 900211, NigeriaViamo Technologies Limited, Abuja 900108, NigeriaKNCV Nigeria, Central Business District, Abuja 900211, NigeriaUnited States Agency for International Development, Central Business District, Abuja 900211, NigeriaUnited States Agency for International Development, Central Business District, Abuja 900211, NigeriaStop TB Partnership, 1218 Geneva, SwitzerlandStop TB Partnership, 1218 Geneva, SwitzerlandUnited States Agency for International Development Global Health Bureau, Washington, DC 20004, USAFederal Ministry of Health, Abuja 900108, NigeriaFederal Ministry of Health, Abuja 900108, NigeriaDepartment of Community Medicine, Osun State University, Osogbo 230101, NigeriaProviding tuberculosis preventive treatment (TPT) to close contacts of persons with TB is a core strategy recommended by WHO for the prevention and control of TB. Nigeria rolled out the 3-month Isoniazid-Rifampicin (3HR) shorter regimen TPT as a pilot for use among eligible adult and child contacts. This study assesses acceptance and completion rates of 3HR TPT among contacts and determines the perspectives of healthcare workers (HCWs) and contacts on acceptance and completion of 3HR TPT in Nigeria. In this cross-sectional descriptive study using mixed methods, records of TPT-eligible clients were retrospectively reviewed, while 18 purposely selected HCWs and 18 contacts on 3HR were interviewed. Of the 30,012 eligible contacts, 12,040 (40.1%) were initiated on TPT. Among these, 8213 (68%) were enrolled on 3HR, and 6972 (84.7%) of them completed treatment. Perceived facilitators include belief in its effectiveness, training among HCWs, and a good understanding of TPT from HCW counseling sessions. Barriers reported were linked to stockouts, misconceptions about side effects, non-disclosures, and disincentive follow-up strategies. The acceptance and completion rate for 3HR TPT was good. Scaling up 3HR TPT will require redesigning policies towards addressing identified barriers and utilizing interventions linked to capabilities, opportunities, and motivations among contacts of TB patients and HCWs.https://www.mdpi.com/2414-6366/9/12/301tuberculosisTB preventive treatmentcontactsNigeria |
| spellingShingle | Austin Ihesie Ogoamaka Chukwuogo Rupert Eneogu Olugbenga Kayode Daniel Aderonke Agbaje Bethrand Odume Debby Nongo Charles Ohikhuai Nera Kadiri-Eneh Omosalewa Oyelaran Victor Obianeri Wayne Van Gemert Enos Okumu Masini Cleophas D’auvergne Urhioke Ochuko Chukwuma Anyaike Sunday Olakunle Olarewaju Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives Tropical Medicine and Infectious Disease tuberculosis TB preventive treatment contacts Nigeria |
| title | Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives |
| title_full | Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives |
| title_fullStr | Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives |
| title_full_unstemmed | Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives |
| title_short | Acceptance and Completion Rates of 3-Month Isoniazid-Rifampicin (3HR) Tuberculosis Preventive Treatment (TPT) Among Contacts of Bacteriologically Confirmed TB Patients—Patients’ and Healthcare Workers’ Perspectives |
| title_sort | acceptance and completion rates of 3 month isoniazid rifampicin 3hr tuberculosis preventive treatment tpt among contacts of bacteriologically confirmed tb patients patients and healthcare workers perspectives |
| topic | tuberculosis TB preventive treatment contacts Nigeria |
| url | https://www.mdpi.com/2414-6366/9/12/301 |
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