Secondary Prevention of Esophageal Variceal Bleeding Using Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Band Ligation plus Beta-Blocker
Aim: This study aims to compare the effectiveness of transjugular intrahepatic portosystemic shunt (TIPS) against combination therapy in the secondary prevention of esophageal variceal bleeding. Method: Literature search was conducted using 4 databases (PubMed, Cochrane, Ovid MEDLINE, and Ovid Emba...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2024-01-01
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| Series: | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
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| Online Access: | https://ina-jghe.com/index.php/jghe/article/view/895 |
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| author | Edward Christopher Yo Saskia Aziza Nursyirwan |
| author_facet | Edward Christopher Yo Saskia Aziza Nursyirwan |
| author_sort | Edward Christopher Yo |
| collection | DOAJ |
| description | Aim: This study aims to compare the effectiveness of transjugular intrahepatic portosystemic shunt (TIPS) against combination therapy in the secondary prevention of esophageal variceal bleeding.
Method: Literature search was conducted using 4 databases (PubMed, Cochrane, Ovid MEDLINE, and Ovid Embase) and individual hand searching. The selected studies were then critically appraised for their validity, importance, and applicability.
Results: A total of 136 results were retrieved, and 2 systematic reviews and meta-analysis of randomized controlled trials (RCTs) were selected. Both studies showed that TIPS significantly decreased incidence of esophageal variceal rebleeding but had no significant effect on reducing overall mortality when compared to combination therapy. Study by Lin et al found that TIPS was significantly better than combination therapy for reducing mortality from variceal rebleeding, but study by Jing et al found no significant difference.
Conclusion: TIPS is superior to combination therapy in reducing the incidence of esophageal variceal rebleeding. Nevertheless, its effectiveness in reducing mortality needs further investigation. Future research should look into its complications and cost-effectiveness in developing countries like Indonesia. |
| format | Article |
| id | doaj-art-61b7bca37b6f4cc1bb1e77e72397848e |
| institution | DOAJ |
| issn | 1411-4801 2302-8181 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| spelling | doaj-art-61b7bca37b6f4cc1bb1e77e72397848e2025-08-20T03:13:36ZengInterna PublishingThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy1411-48012302-81812024-01-0124310.24871/2432023275847Secondary Prevention of Esophageal Variceal Bleeding Using Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Band Ligation plus Beta-BlockerEdward Christopher Yo0Saskia Aziza Nursyirwan1Faculty of Medicine, Universitas Indonesia, JakartaDivision of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, JakartaAim: This study aims to compare the effectiveness of transjugular intrahepatic portosystemic shunt (TIPS) against combination therapy in the secondary prevention of esophageal variceal bleeding. Method: Literature search was conducted using 4 databases (PubMed, Cochrane, Ovid MEDLINE, and Ovid Embase) and individual hand searching. The selected studies were then critically appraised for their validity, importance, and applicability. Results: A total of 136 results were retrieved, and 2 systematic reviews and meta-analysis of randomized controlled trials (RCTs) were selected. Both studies showed that TIPS significantly decreased incidence of esophageal variceal rebleeding but had no significant effect on reducing overall mortality when compared to combination therapy. Study by Lin et al found that TIPS was significantly better than combination therapy for reducing mortality from variceal rebleeding, but study by Jing et al found no significant difference. Conclusion: TIPS is superior to combination therapy in reducing the incidence of esophageal variceal rebleeding. Nevertheless, its effectiveness in reducing mortality needs further investigation. Future research should look into its complications and cost-effectiveness in developing countries like Indonesia.https://ina-jghe.com/index.php/jghe/article/view/895esophageal variceal bleedingtransjugular intrahepatic portosystemic shuntbeta-blockerendoscopic band ligationsecondary prevention |
| spellingShingle | Edward Christopher Yo Saskia Aziza Nursyirwan Secondary Prevention of Esophageal Variceal Bleeding Using Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Band Ligation plus Beta-Blocker The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy esophageal variceal bleeding transjugular intrahepatic portosystemic shunt beta-blocker endoscopic band ligation secondary prevention |
| title | Secondary Prevention of Esophageal Variceal Bleeding Using Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Band Ligation plus Beta-Blocker |
| title_full | Secondary Prevention of Esophageal Variceal Bleeding Using Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Band Ligation plus Beta-Blocker |
| title_fullStr | Secondary Prevention of Esophageal Variceal Bleeding Using Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Band Ligation plus Beta-Blocker |
| title_full_unstemmed | Secondary Prevention of Esophageal Variceal Bleeding Using Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Band Ligation plus Beta-Blocker |
| title_short | Secondary Prevention of Esophageal Variceal Bleeding Using Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Band Ligation plus Beta-Blocker |
| title_sort | secondary prevention of esophageal variceal bleeding using transjugular intrahepatic portosystemic shunt compared to endoscopic band ligation plus beta blocker |
| topic | esophageal variceal bleeding transjugular intrahepatic portosystemic shunt beta-blocker endoscopic band ligation secondary prevention |
| url | https://ina-jghe.com/index.php/jghe/article/view/895 |
| work_keys_str_mv | AT edwardchristopheryo secondarypreventionofesophagealvaricealbleedingusingtransjugularintrahepaticportosystemicshuntcomparedtoendoscopicbandligationplusbetablocker AT saskiaazizanursyirwan secondarypreventionofesophagealvaricealbleedingusingtransjugularintrahepaticportosystemicshuntcomparedtoendoscopicbandligationplusbetablocker |