Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome set

Introduction With treatment-related improvements in survival, rehabilitation is essential to improve function and health-related quality of life and manage the high symptom burden associated with lung cancer. Despite this, significant heterogeneity exists in the outcomes and instruments used to eval...

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Main Authors: Linda Denehy, Lara Edbrooke, Catherine L Granger, Bronwen Connolly, Jill J Francis, Tom John, Nasreen Kaadan, Emma Halloran
Format: Article
Language:English
Published: BMJ Publishing Group 2023-07-01
Series:BMJ Open Respiratory Research
Online Access:https://bmjopenrespres.bmj.com/content/10/1/e001571.full
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author Linda Denehy
Lara Edbrooke
Catherine L Granger
Bronwen Connolly
Jill J Francis
Tom John
Nasreen Kaadan
Emma Halloran
author_facet Linda Denehy
Lara Edbrooke
Catherine L Granger
Bronwen Connolly
Jill J Francis
Tom John
Nasreen Kaadan
Emma Halloran
author_sort Linda Denehy
collection DOAJ
description Introduction With treatment-related improvements in survival, rehabilitation is essential to improve function and health-related quality of life and manage the high symptom burden associated with lung cancer. Despite this, significant heterogeneity exists in the outcomes and instruments used to evaluate lung cancer rehabilitation programme impact. This study aims to develop a core set of clinically relevant lung cancer rehabilitation outcomes for use in clinical practice.Methods and analysis An international Delphi consensus study involving consumer, healthcare professional and researcher stakeholders to determine which outcomes to include and how to measure these. Stage 1 (preliminary): mixed methods to develop the potential list of outcomes (1) overview of systematic reviews of lung cancer exercise interventions and (2) focus groups and individual interviews with people with lung cancer. Stage 2: outcomes were grouped according to the International Classification of Functioning, Disability and Health domains. Stage 3: to determine priority outcomes for core outcome set (COS) inclusion participants will rate each outcome’s importance (one-nine-point Likert scale) over two-three survey rounds. Stage 4: following review by the steering committee, a consensus meeting will be held if agreement on the COS has not been reached.Stage 5: recommendations will be made regarding a single instrument for measuring each COS outcome by reviewing existing resources where consensus has already been reached. Where resources do not exist the quality and feasibility of potential measurement instruments will be appraised, and the Delphi consensus survey and meeting process outlined in stages 3–4 will be repeated.This protocol adheres to the COS-Standardised Protocol statement and will be conducted and reported according to the COS-Standards for Development recommendations and the COS-Standards for Reporting.Ethics and dissemination Ethics approval (20/9/22, University of Melbourne ID 2022-24839-32231-3). Dissemination in peer-reviewed journals and conference presentations.
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spelling doaj-art-61b6493b08ca4c0baa795df8dd4631862025-08-20T02:57:57ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392023-07-0110110.1136/bmjresp-2022-001571Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome setLinda Denehy0Lara Edbrooke1Catherine L Granger2Bronwen Connolly3Jill J Francis4Tom John5Nasreen Kaadan6Emma Halloran716 Allied Health, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia1 Department of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia3 Department of Physiotherapy, The Royal Melbourne Hospital, Melbourne, Victoria, Australia9 Wellcome-Wolfson Institute for Experimental Medicine, Queen`s University Belfast, Belfast, County Antrim, UKSchool of Health Sciences, The University of Melbourne Melbourne School of Health Sciences, Melbourne, Victoria, Australia5 Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia7 Consumer Representative, Sydney, New South Wales, Australia8 Lung Foundation Australia, Milton, Queensland, AustraliaIntroduction With treatment-related improvements in survival, rehabilitation is essential to improve function and health-related quality of life and manage the high symptom burden associated with lung cancer. Despite this, significant heterogeneity exists in the outcomes and instruments used to evaluate lung cancer rehabilitation programme impact. This study aims to develop a core set of clinically relevant lung cancer rehabilitation outcomes for use in clinical practice.Methods and analysis An international Delphi consensus study involving consumer, healthcare professional and researcher stakeholders to determine which outcomes to include and how to measure these. Stage 1 (preliminary): mixed methods to develop the potential list of outcomes (1) overview of systematic reviews of lung cancer exercise interventions and (2) focus groups and individual interviews with people with lung cancer. Stage 2: outcomes were grouped according to the International Classification of Functioning, Disability and Health domains. Stage 3: to determine priority outcomes for core outcome set (COS) inclusion participants will rate each outcome’s importance (one-nine-point Likert scale) over two-three survey rounds. Stage 4: following review by the steering committee, a consensus meeting will be held if agreement on the COS has not been reached.Stage 5: recommendations will be made regarding a single instrument for measuring each COS outcome by reviewing existing resources where consensus has already been reached. Where resources do not exist the quality and feasibility of potential measurement instruments will be appraised, and the Delphi consensus survey and meeting process outlined in stages 3–4 will be repeated.This protocol adheres to the COS-Standardised Protocol statement and will be conducted and reported according to the COS-Standards for Development recommendations and the COS-Standards for Reporting.Ethics and dissemination Ethics approval (20/9/22, University of Melbourne ID 2022-24839-32231-3). Dissemination in peer-reviewed journals and conference presentations.https://bmjopenrespres.bmj.com/content/10/1/e001571.full
spellingShingle Linda Denehy
Lara Edbrooke
Catherine L Granger
Bronwen Connolly
Jill J Francis
Tom John
Nasreen Kaadan
Emma Halloran
Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome set
BMJ Open Respiratory Research
title Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome set
title_full Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome set
title_fullStr Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome set
title_full_unstemmed Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome set
title_short Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome set
title_sort rehabilitation outcomes for people with lung cancer unite protocol for the development of a core outcome set
url https://bmjopenrespres.bmj.com/content/10/1/e001571.full
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