Impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes: a nationwide study
Abstract This study aims to investigate the incidence of new-onset atrial fibrillation (AF) in individuals with type 2 diabetes mellitus (T2DM) across different categories of steatotic liver disease (SLD). Using a health examination database between 2009 and 2012, this study included 2,480,880 patie...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-94783-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850153656186306560 |
|---|---|
| author | So Hyun Cho Gyuri Kim Kyu-na Lee Rosa Oh Ji Yoon Kim Myunghwa Jang You-Bin Lee Sang-Man Jin Kyu Yeon Hur Kyungdo Han Jae Hyeon Kim |
| author_facet | So Hyun Cho Gyuri Kim Kyu-na Lee Rosa Oh Ji Yoon Kim Myunghwa Jang You-Bin Lee Sang-Man Jin Kyu Yeon Hur Kyungdo Han Jae Hyeon Kim |
| author_sort | So Hyun Cho |
| collection | DOAJ |
| description | Abstract This study aims to investigate the incidence of new-onset atrial fibrillation (AF) in individuals with type 2 diabetes mellitus (T2DM) across different categories of steatotic liver disease (SLD). Using a health examination database between 2009 and 2012, this study included 2,480,880 patients. Participants were categorized into five groups based on hepatic steatosis (fatty liver index ≥ 60), cardiometabolic risk factors, and alcohol consumption. Cox regression analyses were performed. The metabolic dysfunction-associated steatotic liver disease (MASLD) group showed an increased risk of new-onset AF (adjusted hazard ratio (aHR), 1.10; 95% confidence interval (CI), 1.08–1.11). The MASLD with other combined group demonstrated increased AF development (aHR, 1.22; 95% CI, 1.18–1.26). In metabolic dysfunction and alcohol-related steatotic liver disease (MetALD) and alcohol-related liver disease (ALD) with metabolic groups, heavy to excessive alcohol consumption increased the risk of AF incidence, with the highest aHR associated with greater alcohol intake (aHR, 1.26; 95% CI, 1.22–1.29, 1.48; 95% CI, 1.41–1.55). MASLD increased the risk of AF in patients with T2DM, with a higher risk observed when accompanied by other liver diseases. Alcohol consumption was associated with proportional increase in the risk of AF, with excessive alcohol consumption associated with the highest risk of AF. |
| format | Article |
| id | doaj-art-61b2f10ba4c840e9a3c0c351c88096f2 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-61b2f10ba4c840e9a3c0c351c88096f22025-08-20T02:25:40ZengNature PortfolioScientific Reports2045-23222025-04-0115111010.1038/s41598-025-94783-8Impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes: a nationwide studySo Hyun Cho0Gyuri Kim1Kyu-na Lee2Rosa Oh3Ji Yoon Kim4Myunghwa Jang5You-Bin Lee6Sang-Man Jin7Kyu Yeon Hur8Kyungdo Han9Jae Hyeon Kim10Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Biomedicine & Health Sciences, College of Medicine, The Catholic University of KoreaDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Statistics and Actuarial Science, Soongsil UniversityDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract This study aims to investigate the incidence of new-onset atrial fibrillation (AF) in individuals with type 2 diabetes mellitus (T2DM) across different categories of steatotic liver disease (SLD). Using a health examination database between 2009 and 2012, this study included 2,480,880 patients. Participants were categorized into five groups based on hepatic steatosis (fatty liver index ≥ 60), cardiometabolic risk factors, and alcohol consumption. Cox regression analyses were performed. The metabolic dysfunction-associated steatotic liver disease (MASLD) group showed an increased risk of new-onset AF (adjusted hazard ratio (aHR), 1.10; 95% confidence interval (CI), 1.08–1.11). The MASLD with other combined group demonstrated increased AF development (aHR, 1.22; 95% CI, 1.18–1.26). In metabolic dysfunction and alcohol-related steatotic liver disease (MetALD) and alcohol-related liver disease (ALD) with metabolic groups, heavy to excessive alcohol consumption increased the risk of AF incidence, with the highest aHR associated with greater alcohol intake (aHR, 1.26; 95% CI, 1.22–1.29, 1.48; 95% CI, 1.41–1.55). MASLD increased the risk of AF in patients with T2DM, with a higher risk observed when accompanied by other liver diseases. Alcohol consumption was associated with proportional increase in the risk of AF, with excessive alcohol consumption associated with the highest risk of AF.https://doi.org/10.1038/s41598-025-94783-8Alcohol consumptionAtrial fibrillationDiabetesFatty liver indexMetabolic dysfunction-associated steatotic liver disease |
| spellingShingle | So Hyun Cho Gyuri Kim Kyu-na Lee Rosa Oh Ji Yoon Kim Myunghwa Jang You-Bin Lee Sang-Man Jin Kyu Yeon Hur Kyungdo Han Jae Hyeon Kim Impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes: a nationwide study Scientific Reports Alcohol consumption Atrial fibrillation Diabetes Fatty liver index Metabolic dysfunction-associated steatotic liver disease |
| title | Impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes: a nationwide study |
| title_full | Impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes: a nationwide study |
| title_fullStr | Impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes: a nationwide study |
| title_full_unstemmed | Impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes: a nationwide study |
| title_short | Impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes: a nationwide study |
| title_sort | impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes a nationwide study |
| topic | Alcohol consumption Atrial fibrillation Diabetes Fatty liver index Metabolic dysfunction-associated steatotic liver disease |
| url | https://doi.org/10.1038/s41598-025-94783-8 |
| work_keys_str_mv | AT sohyuncho impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy AT gyurikim impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy AT kyunalee impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy AT rosaoh impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy AT jiyoonkim impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy AT myunghwajang impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy AT youbinlee impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy AT sangmanjin impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy AT kyuyeonhur impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy AT kyungdohan impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy AT jaehyeonkim impactofsteatoticliverdiseasecategoriesonatrialfibrillationintype2diabetesanationwidestudy |