Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis
Purpose: The purpose of this study is the prevention of Candida colonies on PMMA Denture Base by altering the surface and incorporations of Nanoparticles. Materials and methods: The Pub Med/Medline was searched to identify 100 relevant studies published from 2011 to 2020. The search strategy employe...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-04-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426820300464 |
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| author | Nafis Ahmad, Professor, MDS Zeba Jafri, Professor, MDS Zishan H. Khan, Professor, Ph.D |
| author_facet | Nafis Ahmad, Professor, MDS Zeba Jafri, Professor, MDS Zishan H. Khan, Professor, Ph.D |
| author_sort | Nafis Ahmad, Professor, MDS |
| collection | DOAJ |
| description | Purpose: The purpose of this study is the prevention of Candida colonies on PMMA Denture Base by altering the surface and incorporations of Nanoparticles. Materials and methods: The Pub Med/Medline was searched to identify 100 relevant studies published from 2011 to 2020. The search strategy employed the following keywords related to “use of Nanoparticles in dentistry”, “Antimicrobial agents and PMMA”, “Candidiasis and nanomaterials”, “Prevention of oral Candidiasis”, “Incorporation of antimicrobial agents in acrylic dentures,” “nanoparticles as therapeutic agents for denture stomatitis”, “Nanodentistry” or “Nanotechnology” or “Nanocomposite” or “Nanodrugs” or “Nanomaterials”. Results: Most of the studies shows that modified PMMA denture base resin containing different antimicrobial coatings and incorporation of metal oxides Nanoparticles and other nanomaterials showed antifungal activity in vitro; however some materials in higher concentration showing altered physical and mechanical properties possibly due to aggregation of Nanoparticles in the lattice of PMMA molecules. Conclusion: Metal oxides nanomaterials revealed cytotoxicity to Candida and other microbes present in oral biofilm including PMMA denture surface. Nano toxicity may attribute to direct interaction of nanoparticles with cell membrane, hindrance in protein synthesis and early adhesion & interfere with physiology of pathogens. |
| format | Article |
| id | doaj-art-61b2da4dcb01431ca7157624d61b174e |
| institution | DOAJ |
| issn | 2212-4268 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-61b2da4dcb01431ca7157624d61b174e2025-08-20T02:50:27ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682020-04-0110218919310.1016/j.jobcr.2020.04.012Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysisNafis Ahmad, Professor, MDS0Zeba Jafri, Professor, MDS1Zishan H. Khan, Professor, Ph.D2Dept of Prosthodontics, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India; Corresponding author.Dept of Periodontics, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, IndiaDept. of Applied Science & Humanities, Faculty of Engineering &Technology, Jamia Millia Islamia, New Delhi, IndiaPurpose: The purpose of this study is the prevention of Candida colonies on PMMA Denture Base by altering the surface and incorporations of Nanoparticles. Materials and methods: The Pub Med/Medline was searched to identify 100 relevant studies published from 2011 to 2020. The search strategy employed the following keywords related to “use of Nanoparticles in dentistry”, “Antimicrobial agents and PMMA”, “Candidiasis and nanomaterials”, “Prevention of oral Candidiasis”, “Incorporation of antimicrobial agents in acrylic dentures,” “nanoparticles as therapeutic agents for denture stomatitis”, “Nanodentistry” or “Nanotechnology” or “Nanocomposite” or “Nanodrugs” or “Nanomaterials”. Results: Most of the studies shows that modified PMMA denture base resin containing different antimicrobial coatings and incorporation of metal oxides Nanoparticles and other nanomaterials showed antifungal activity in vitro; however some materials in higher concentration showing altered physical and mechanical properties possibly due to aggregation of Nanoparticles in the lattice of PMMA molecules. Conclusion: Metal oxides nanomaterials revealed cytotoxicity to Candida and other microbes present in oral biofilm including PMMA denture surface. Nano toxicity may attribute to direct interaction of nanoparticles with cell membrane, hindrance in protein synthesis and early adhesion & interfere with physiology of pathogens.http://www.sciencedirect.com/science/article/pii/S2212426820300464NanotechnologyOral biofilmOral candidiasisNanoparticles & nanomaterialsPolymethyl meth acrylate (PMMA)Nanodentistry |
| spellingShingle | Nafis Ahmad, Professor, MDS Zeba Jafri, Professor, MDS Zishan H. Khan, Professor, Ph.D Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis Journal of Oral Biology and Craniofacial Research Nanotechnology Oral biofilm Oral candidiasis Nanoparticles & nanomaterials Polymethyl meth acrylate (PMMA) Nanodentistry |
| title | Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis |
| title_full | Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis |
| title_fullStr | Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis |
| title_full_unstemmed | Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis |
| title_short | Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis |
| title_sort | evaluation of nanomaterials to prevent oral candidiasis in pmma based denture wearing patients a systematic analysis |
| topic | Nanotechnology Oral biofilm Oral candidiasis Nanoparticles & nanomaterials Polymethyl meth acrylate (PMMA) Nanodentistry |
| url | http://www.sciencedirect.com/science/article/pii/S2212426820300464 |
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