Evaluation of Antioxidants, Antibacterial and Antidiabetic Activities of Aqua-alcoholic Marjoram Extract
Plant extracts possess special significance towards human health and vital activities for a wide range of diseases. The current study aims at verifying the presence of active ingredients in marjoram leaves extract, and determining antioxidants, antibacterial and antifungal activities, LD50 and its...
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University of Baghdad, College of Science for Women
2024-08-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9328 |
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| author | Kadhim K. Ghudhaib Fayhaa M. Khaleel |
| author_facet | Kadhim K. Ghudhaib Fayhaa M. Khaleel |
| author_sort | Kadhim K. Ghudhaib |
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Plant extracts possess special significance towards human health and vital activities for a wide range of diseases. The current study aims at verifying the presence of active ingredients in marjoram leaves extract, and determining antioxidants, antibacterial and antifungal activities, LD50 and its antidiabetic activity. The active ingredients were qualitatively analyzed by specific test methods. Antioxidant, LD50, antibacterial and antifungal activities were measured by their standard method. The antidiabetic activity was determined by assessed hyperglycemia, hyperlipidemia and liver functions by spectrophotometric methods. The results confirmed the presence of several active components including flavonoids, alkaloids, terpenoids, tannins, and saponins. Also, the results of antioxidants activity showed that marjoram leaves extract possesses an antioxidant activity similar to ascorbic acid. LD50 results revealed that the allowed dose is 12.5 mg/ml. Biological activity results indicated that marjoram leaves extract possesses antibacterial and antifungal activities against wide range of pathogenic bacteria and fungi, but there is no effect of extract on E. coli and Staphylococcus aureus even at high concentrations. Marjoram extract revealed high antidiabetic activity when treated for two weeks 4mg of the extract daily. Also, lipid profile and liver functions, and testosterone levels were improved after treatment in the diabetic group related to the control group. It can be concluded that marjoram leaves extract has high antioxidant activity with high biological activity and high antidiabetic activity with a significant enhancement of fertility affected in diabetes and a high level of tolerated doses according to the LD50 value.
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| format | Article |
| id | doaj-art-61b0afaa30a84753a5ff0bd1cd1d56ed |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | University of Baghdad, College of Science for Women |
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| series | مجلة بغداد للعلوم |
| spelling | doaj-art-61b0afaa30a84753a5ff0bd1cd1d56ed2025-08-20T03:56:22ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-08-0121810.21123/bsj.2024.9328Evaluation of Antioxidants, Antibacterial and Antidiabetic Activities of Aqua-alcoholic Marjoram ExtractKadhim K. Ghudhaib0https://orcid.org/0000-0003-4966-4070Fayhaa M. Khaleel1Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq. Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq. Plant extracts possess special significance towards human health and vital activities for a wide range of diseases. The current study aims at verifying the presence of active ingredients in marjoram leaves extract, and determining antioxidants, antibacterial and antifungal activities, LD50 and its antidiabetic activity. The active ingredients were qualitatively analyzed by specific test methods. Antioxidant, LD50, antibacterial and antifungal activities were measured by their standard method. The antidiabetic activity was determined by assessed hyperglycemia, hyperlipidemia and liver functions by spectrophotometric methods. The results confirmed the presence of several active components including flavonoids, alkaloids, terpenoids, tannins, and saponins. Also, the results of antioxidants activity showed that marjoram leaves extract possesses an antioxidant activity similar to ascorbic acid. LD50 results revealed that the allowed dose is 12.5 mg/ml. Biological activity results indicated that marjoram leaves extract possesses antibacterial and antifungal activities against wide range of pathogenic bacteria and fungi, but there is no effect of extract on E. coli and Staphylococcus aureus even at high concentrations. Marjoram extract revealed high antidiabetic activity when treated for two weeks 4mg of the extract daily. Also, lipid profile and liver functions, and testosterone levels were improved after treatment in the diabetic group related to the control group. It can be concluded that marjoram leaves extract has high antioxidant activity with high biological activity and high antidiabetic activity with a significant enhancement of fertility affected in diabetes and a high level of tolerated doses according to the LD50 value. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9328Antibacterial activity, Antidiabetic activity, Antifungal activity, Antioxidant activity, Marjoram extract |
| spellingShingle | Kadhim K. Ghudhaib Fayhaa M. Khaleel Evaluation of Antioxidants, Antibacterial and Antidiabetic Activities of Aqua-alcoholic Marjoram Extract مجلة بغداد للعلوم Antibacterial activity, Antidiabetic activity, Antifungal activity, Antioxidant activity, Marjoram extract |
| title | Evaluation of Antioxidants, Antibacterial and Antidiabetic Activities of Aqua-alcoholic Marjoram Extract |
| title_full | Evaluation of Antioxidants, Antibacterial and Antidiabetic Activities of Aqua-alcoholic Marjoram Extract |
| title_fullStr | Evaluation of Antioxidants, Antibacterial and Antidiabetic Activities of Aqua-alcoholic Marjoram Extract |
| title_full_unstemmed | Evaluation of Antioxidants, Antibacterial and Antidiabetic Activities of Aqua-alcoholic Marjoram Extract |
| title_short | Evaluation of Antioxidants, Antibacterial and Antidiabetic Activities of Aqua-alcoholic Marjoram Extract |
| title_sort | evaluation of antioxidants antibacterial and antidiabetic activities of aqua alcoholic marjoram extract |
| topic | Antibacterial activity, Antidiabetic activity, Antifungal activity, Antioxidant activity, Marjoram extract |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9328 |
| work_keys_str_mv | AT kadhimkghudhaib evaluationofantioxidantsantibacterialandantidiabeticactivitiesofaquaalcoholicmarjoramextract AT fayhaamkhaleel evaluationofantioxidantsantibacterialandantidiabeticactivitiesofaquaalcoholicmarjoramextract |