Repurposing of Furin Inhibitors to Reduce Pathogenic <i>E. coli</i>- and <i>Shigella flexneri</i>-Induced Cytotoxicity, Oxidative Stress and Inflammation in Mammalian Epithelial Cells

Repurposing of Furin Inhibitors to Reduce Pathogenic <i>E. coli</i>- and <i>Shigella flexneri</i>-Induced Cytotoxicity, Oxidative Stress and Inflammation in Mammalian Epithelial Cells

Background/Objectives: Enterobacteriaceae, including pathogenic <i>Shigella</i> (<i>S.</i>) <i>flexneri</i> and <i>Escherichia</i> (<i>E.</i>) <i>coli</i>, cause severe gastrointestinal infections through toxins like Shiga and S...

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Bibliographic Details
Main Authors: Isabella Rumer, Lilla Tóth, Annelie Wohlert, András Adorján, Ákos Jerzsele, Roman W. Lange, Torsten Steinmetzer, Erzsébet Gere-Pászti
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Antibiotics
Subjects:
furin inhibitors
enterohemorrhagic <i>E. coli</i>
IPEC-J2 cells
Shiga toxin
oxidative stress
inflammatory cytokines
Online Access:https://www.mdpi.com/2079-6382/14/5/431
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