Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention
Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor subtype γ (PPARγ) activators that are clinically used as an insulin sensitizer for glycemic control in patients with type 2 diabetes. Additionally, TZDs exhibit novel anti-inflammatory, antioxidant, and antiproliferative proper...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/943614 |
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| author | Tianxin Yang Sunhapas Soodvilai |
| author_facet | Tianxin Yang Sunhapas Soodvilai |
| author_sort | Tianxin Yang |
| collection | DOAJ |
| description | Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor subtype γ (PPARγ) activators that are clinically used as an insulin sensitizer for glycemic control in patients with type 2 diabetes. Additionally, TZDs exhibit novel anti-inflammatory, antioxidant, and antiproliferative properties, indicating therapeutic potential for a wide variety of diseases associated with diabetes and other conditions. The clinical applications of TZDs are limited by the common major side effect of fluid retention. A better understanding of the molecular mechanism of TZD-induced fluid retention is essential for the development of novel therapies with improved safety profiles. An important breakthrough in the field is the finding that the renal collecting duct is a major site for increased fluid reabsorption in response to rosiglitazone or pioglitazone. New evidence also indicates that increased vascular permeability in adipose tissues may contribute to edema formation and body weight gain. Future research should therefore be directed at achieving a better understanding of the detailed mechanisms of TZD-induced increases in renal sodium transport and in vascular permeability. |
| format | Article |
| id | doaj-art-61afe6cca8364a8288890438457824c0 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-61afe6cca8364a8288890438457824c02025-02-03T01:00:27ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/943614943614Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid RetentionTianxin Yang0Sunhapas Soodvilai1Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, UT 84132-2412, USADepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, UT 84132-2412, USAThiazolidinediones (TZDs) are peroxisome proliferator-activated receptor subtype γ (PPARγ) activators that are clinically used as an insulin sensitizer for glycemic control in patients with type 2 diabetes. Additionally, TZDs exhibit novel anti-inflammatory, antioxidant, and antiproliferative properties, indicating therapeutic potential for a wide variety of diseases associated with diabetes and other conditions. The clinical applications of TZDs are limited by the common major side effect of fluid retention. A better understanding of the molecular mechanism of TZD-induced fluid retention is essential for the development of novel therapies with improved safety profiles. An important breakthrough in the field is the finding that the renal collecting duct is a major site for increased fluid reabsorption in response to rosiglitazone or pioglitazone. New evidence also indicates that increased vascular permeability in adipose tissues may contribute to edema formation and body weight gain. Future research should therefore be directed at achieving a better understanding of the detailed mechanisms of TZD-induced increases in renal sodium transport and in vascular permeability.http://dx.doi.org/10.1155/2008/943614 |
| spellingShingle | Tianxin Yang Sunhapas Soodvilai Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention PPAR Research |
| title | Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention |
| title_full | Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention |
| title_fullStr | Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention |
| title_full_unstemmed | Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention |
| title_short | Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention |
| title_sort | renal and vascular mechanisms of thiazolidinedione induced fluid retention |
| url | http://dx.doi.org/10.1155/2008/943614 |
| work_keys_str_mv | AT tianxinyang renalandvascularmechanismsofthiazolidinedioneinducedfluidretention AT sunhapassoodvilai renalandvascularmechanismsofthiazolidinedioneinducedfluidretention |