From the bench of molecular understanding to the bedside of optimal therapy for BCR::ABL1 and ABL-class acute lymphoblastic leukemia in children and adolescents

From the bench of molecular understanding to the bedside of optimal therapy for BCR::ABL1 and ABL-class acute lymphoblastic leukemia in children and adolescents

This review aims to discuss similarities and dissimilarities between BCR::ABL1-rearranged (Philadelphia chromosome-positive [Ph+]) and ABL-class fusion-driven BCR::ABL1-like (Ph-like) acute lymphoblastic leukemia (ALL) in children and adolescents. Recent insights into the biology of these historical...

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Bibliographic Details
Main Authors: Sarah K. Tasian, Judith M. Boer, Monique L. den Boer
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:EJC Paediatric Oncology
Subjects:
ABL-class
Acute lymphoblastic leukemia
BCR::ABL1
BCR::ABL1-like
Children
Clinical trials
Online Access:http://www.sciencedirect.com/science/article/pii/S2772610X25000923
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