Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure.

Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure.

Metabolism of xenobiotics by cytochrome P450s (encoded by the CYP genes) often leads to bio-activation, producing reactive metabolites that interfere with cellular processes and cause DNA damage. In the testes, DNA damage induced by xenobiotics has been associated with impaired spermatogenesis and a...

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Bibliographic Details
Main Authors: Belinda J Nixon, Aimee L Katen, Simone J Stanger, John E Schjenken, Brett Nixon, Shaun D Roman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094904&type=printable
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