An Interactive Database of Cocaine-Responsive Gene Expression
The postgenomic era of large-scale gene expression studies is inundating drug abuse researchers and many other scientists with findings related to gene expression. This information is distributed across many different journals, and requires laborious literature searches. Here, we present an interact...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.145 |
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| _version_ | 1832564686417035264 |
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| author | Willard M. Freeman Kathryn E. Dougherty Sally E. Vacca Kent E. Vrana |
| author_facet | Willard M. Freeman Kathryn E. Dougherty Sally E. Vacca Kent E. Vrana |
| author_sort | Willard M. Freeman |
| collection | DOAJ |
| description | The postgenomic era of large-scale gene expression studies is inundating drug abuse researchers and many other scientists with findings related to gene expression. This information is distributed across many different journals, and requires laborious literature searches. Here, we present an interactive database that combines existing information related to cocaine-mediated changes in gene expression in an easy-to-use format. The database is limited to statistically significant changes in mRNA or protein expression after cocaine administration. The Flash-based program is integrated into a Web page, and organizes changes in gene expression based on neuroanatomical region, general function, and gene name. Accompanying each gene is a description of the gene, links to the original publications, and a link to the appropriate OMIM (Online Mendelian Inheritance in Man) entry. The nature of this review allows for timely modifications and rapid inclusion of new publications, and should help researchers build second-generation hypotheses on the role of gene expression changes in the physiology and behavior of cocaine abuse. Furthermore, this method of organizing large volumes of scientific information can easily be adapted to assist researchers in fields outside of drug abuse. |
| format | Article |
| id | doaj-art-61a7f0d872e247d8b4c876ee1482fce9 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-61a7f0d872e247d8b4c876ee1482fce92025-02-03T01:10:28ZengWileyThe Scientific World Journal1537-744X2002-01-01270170610.1100/tsw.2002.145An Interactive Database of Cocaine-Responsive Gene ExpressionWillard M. Freeman0Kathryn E. Dougherty1Sally E. Vacca2Kent E. Vrana3Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1083, USACenter for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1083, USACenter for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1083, USACenter for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1083, USAThe postgenomic era of large-scale gene expression studies is inundating drug abuse researchers and many other scientists with findings related to gene expression. This information is distributed across many different journals, and requires laborious literature searches. Here, we present an interactive database that combines existing information related to cocaine-mediated changes in gene expression in an easy-to-use format. The database is limited to statistically significant changes in mRNA or protein expression after cocaine administration. The Flash-based program is integrated into a Web page, and organizes changes in gene expression based on neuroanatomical region, general function, and gene name. Accompanying each gene is a description of the gene, links to the original publications, and a link to the appropriate OMIM (Online Mendelian Inheritance in Man) entry. The nature of this review allows for timely modifications and rapid inclusion of new publications, and should help researchers build second-generation hypotheses on the role of gene expression changes in the physiology and behavior of cocaine abuse. Furthermore, this method of organizing large volumes of scientific information can easily be adapted to assist researchers in fields outside of drug abuse.http://dx.doi.org/10.1100/tsw.2002.145 |
| spellingShingle | Willard M. Freeman Kathryn E. Dougherty Sally E. Vacca Kent E. Vrana An Interactive Database of Cocaine-Responsive Gene Expression The Scientific World Journal |
| title | An Interactive Database of Cocaine-Responsive Gene Expression |
| title_full | An Interactive Database of Cocaine-Responsive Gene Expression |
| title_fullStr | An Interactive Database of Cocaine-Responsive Gene Expression |
| title_full_unstemmed | An Interactive Database of Cocaine-Responsive Gene Expression |
| title_short | An Interactive Database of Cocaine-Responsive Gene Expression |
| title_sort | interactive database of cocaine responsive gene expression |
| url | http://dx.doi.org/10.1100/tsw.2002.145 |
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