Xenon Anesthesia Improves Respiratory Gas Exchanges in Morbidly Obese Patients
Background. Xenon-in-oxygen is a high density gas mixture and may improve PaO2/FiO2 ratio in morbidly obese patients uniforming distribution of ventilation during anesthesia. Methods. We compared xenon versus sevoflurane anesthesia in twenty adult morbidly obese patients (BMI>35) candidate for ro...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2010/421593 |
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| author | Antonio Abramo Claudio Di Salvo Francesca Foltran Francesco Forfori Marco Anselmino Francesco Giunta |
| author_facet | Antonio Abramo Claudio Di Salvo Francesca Foltran Francesco Forfori Marco Anselmino Francesco Giunta |
| author_sort | Antonio Abramo |
| collection | DOAJ |
| description | Background. Xenon-in-oxygen is a high density gas mixture and may improve PaO2/FiO2 ratio in morbidly obese patients uniforming distribution of ventilation during anesthesia. Methods. We compared xenon versus sevoflurane anesthesia in twenty adult morbidly obese patients (BMI>35) candidate for roux-en-Y laparoscopic gastric bypass and assessed PaO2/FiO2 ratio at baseline, at 15 min from induction of anaesthesia and every 60 min during surgery. Differences in intraoperative and postoperative data including heart rate, systolic and diastolic pressure, oxygen saturation, plateau pressure, eyes opening and extubation time, Aldrete score on arrival to the PACU were compared by the Mann-Whitney test and were considered as secondary aims. Moreover the occurrence of side effects and postoperative analgesic demand were assessed. Results. In xenon group PaO2-FiO2 ratio was significantly higher after 60 min and 120 min from induction of anesthesia; heart rate and overall remifentanil consumption were lower; the eyes opening time and the extubation time were shorter; morphine consumption at 72 hours was lower; postoperative nausea was more common. Conclusions. Xenon anesthesia improved PaO2/FiO2 ratio and maintained its distinctive rapid recovery times and cardiovascular stability. A reduction of opioid consumption during and after surgery and an increased incidence of PONV were also observed in xenon group. |
| format | Article |
| id | doaj-art-61a5f17626de49368e6ccec87bc6ceff |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-61a5f17626de49368e6ccec87bc6ceff2025-02-03T01:25:59ZengWileyJournal of Obesity2090-07082090-07162010-01-01201010.1155/2010/421593421593Xenon Anesthesia Improves Respiratory Gas Exchanges in Morbidly Obese PatientsAntonio Abramo0Claudio Di Salvo1Francesca Foltran2Francesco Forfori3Marco Anselmino4Francesco Giunta5Anestesia e Rianimazione Universitaria IV, Azienda Ospedaliera Universitaria Pisana, Via Roma 67, Pisa 56100, ItalyAnestesia e Rianimazione Universitaria IV, Azienda Ospedaliera Universitaria Pisana, Via Roma 67, Pisa 56100, ItalyAnestesia e Rianimazione Universitaria IV, Azienda Ospedaliera Universitaria Pisana, Via Roma 67, Pisa 56100, ItalyAnestesia e Rianimazione Universitaria IV, Azienda Ospedaliera Universitaria Pisana, Via Roma 67, Pisa 56100, ItalyBariatric Surgery Unit, Azienda Ospedaliera Universitaria Pisana, Via Roma 67, Pisa 56100, ItalyAnestesia e Rianimazione Universitaria IV, Azienda Ospedaliera Universitaria Pisana, Via Roma 67, Pisa 56100, ItalyBackground. Xenon-in-oxygen is a high density gas mixture and may improve PaO2/FiO2 ratio in morbidly obese patients uniforming distribution of ventilation during anesthesia. Methods. We compared xenon versus sevoflurane anesthesia in twenty adult morbidly obese patients (BMI>35) candidate for roux-en-Y laparoscopic gastric bypass and assessed PaO2/FiO2 ratio at baseline, at 15 min from induction of anaesthesia and every 60 min during surgery. Differences in intraoperative and postoperative data including heart rate, systolic and diastolic pressure, oxygen saturation, plateau pressure, eyes opening and extubation time, Aldrete score on arrival to the PACU were compared by the Mann-Whitney test and were considered as secondary aims. Moreover the occurrence of side effects and postoperative analgesic demand were assessed. Results. In xenon group PaO2-FiO2 ratio was significantly higher after 60 min and 120 min from induction of anesthesia; heart rate and overall remifentanil consumption were lower; the eyes opening time and the extubation time were shorter; morphine consumption at 72 hours was lower; postoperative nausea was more common. Conclusions. Xenon anesthesia improved PaO2/FiO2 ratio and maintained its distinctive rapid recovery times and cardiovascular stability. A reduction of opioid consumption during and after surgery and an increased incidence of PONV were also observed in xenon group.http://dx.doi.org/10.1155/2010/421593 |
| spellingShingle | Antonio Abramo Claudio Di Salvo Francesca Foltran Francesco Forfori Marco Anselmino Francesco Giunta Xenon Anesthesia Improves Respiratory Gas Exchanges in Morbidly Obese Patients Journal of Obesity |
| title | Xenon Anesthesia Improves Respiratory Gas Exchanges in Morbidly Obese Patients |
| title_full | Xenon Anesthesia Improves Respiratory Gas Exchanges in Morbidly Obese Patients |
| title_fullStr | Xenon Anesthesia Improves Respiratory Gas Exchanges in Morbidly Obese Patients |
| title_full_unstemmed | Xenon Anesthesia Improves Respiratory Gas Exchanges in Morbidly Obese Patients |
| title_short | Xenon Anesthesia Improves Respiratory Gas Exchanges in Morbidly Obese Patients |
| title_sort | xenon anesthesia improves respiratory gas exchanges in morbidly obese patients |
| url | http://dx.doi.org/10.1155/2010/421593 |
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