Feasibility assessment of a pharmaco-kinetic behavior based yield model of salivary cotinine among tobacco users
Methods: A secondary analysis was conducted using puff topography and salivary cotinine biomarker data from a prior two arm, two period cross-over study conducted in the natural environment over 17 days which enrolled 55 Juul electronic cigarette users. The study expands upon a previously validated...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750025000162 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595757157318656 |
|---|---|
| author | E.C. Hensel R.J. Robinson |
| author_facet | E.C. Hensel R.J. Robinson |
| author_sort | E.C. Hensel |
| collection | DOAJ |
| description | Methods: A secondary analysis was conducted using puff topography and salivary cotinine biomarker data from a prior two arm, two period cross-over study conducted in the natural environment over 17 days which enrolled 55 Juul electronic cigarette users. The study expands upon a previously validated behavior-based yield (BBY) which quantified aerosol emissions from a Juul ecig as a function of user behavior. A Pharmacokinetic Behavior-Based Yield (PkBBY) model is introduced which models the uptake of nicotine into the body and its subsequent metabolic decay into cotinine. A subset of the available participant data was used to train the PkBBY model and identify three parameters: a gain reflecting the conversion of nicotine into salivary cotinine concentration, and the half-lives of nicotine and salivary cotinine in the body. A separate subset of the available data was used for assessing performance of the PkBBY model against salivary cotinine biomarkers of exposure. Results: Model training demonstrated the PkBBY model was able to predict the bedtime salivary cotinine of participants within + /- 220 ng/mL 95 % confidence interval on the regression, based on their observed puff topography. The training algorithm estimated the conversion from nicotine ingested into the concentration of salivary cotinine as 28.8 [(ng/mL cotinine)/(mg nicotine ingested)], and the half-lives of nicotine and cotinine to be 4.4 and 49 [hours], respectively. The one-to-one intraclass correlation coefficient of the model applied to the assessment data set was 0.6, indicating moderate agreement between the predictions and the observed biomarkers, Limitations of the model associated with the data available for secondary analysis are discussed. Conclusions: The PkBBY model was internally validated and shows promise as a tool for establishing a causal relationship between puffing behavior and an established biomarker of nicotine exposure. Further work is needed to develop personalized PkBBY model parameters to account for variations in participant metabolism factors. |
| format | Article |
| id | doaj-art-619ea9cac9e04c1c95782ce4d48c9ef4 |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-619ea9cac9e04c1c95782ce4d48c9ef42025-01-18T05:04:42ZengElsevierToxicology Reports2214-75002025-06-0114101898Feasibility assessment of a pharmaco-kinetic behavior based yield model of salivary cotinine among tobacco usersE.C. Hensel0R.J. Robinson1Correspondence to: 98 Lomb Memorial Drive, Rochester, NY 14623-5604, United States.; Department of Mechanical Engineering, Rochester Institute of Technology, Rochester, NY, United StatesDepartment of Mechanical Engineering, Rochester Institute of Technology, Rochester, NY, United StatesMethods: A secondary analysis was conducted using puff topography and salivary cotinine biomarker data from a prior two arm, two period cross-over study conducted in the natural environment over 17 days which enrolled 55 Juul electronic cigarette users. The study expands upon a previously validated behavior-based yield (BBY) which quantified aerosol emissions from a Juul ecig as a function of user behavior. A Pharmacokinetic Behavior-Based Yield (PkBBY) model is introduced which models the uptake of nicotine into the body and its subsequent metabolic decay into cotinine. A subset of the available participant data was used to train the PkBBY model and identify three parameters: a gain reflecting the conversion of nicotine into salivary cotinine concentration, and the half-lives of nicotine and salivary cotinine in the body. A separate subset of the available data was used for assessing performance of the PkBBY model against salivary cotinine biomarkers of exposure. Results: Model training demonstrated the PkBBY model was able to predict the bedtime salivary cotinine of participants within + /- 220 ng/mL 95 % confidence interval on the regression, based on their observed puff topography. The training algorithm estimated the conversion from nicotine ingested into the concentration of salivary cotinine as 28.8 [(ng/mL cotinine)/(mg nicotine ingested)], and the half-lives of nicotine and cotinine to be 4.4 and 49 [hours], respectively. The one-to-one intraclass correlation coefficient of the model applied to the assessment data set was 0.6, indicating moderate agreement between the predictions and the observed biomarkers, Limitations of the model associated with the data available for secondary analysis are discussed. Conclusions: The PkBBY model was internally validated and shows promise as a tool for establishing a causal relationship between puffing behavior and an established biomarker of nicotine exposure. Further work is needed to develop personalized PkBBY model parameters to account for variations in participant metabolism factors.http://www.sciencedirect.com/science/article/pii/S2214750025000162Electronic cigaretteSalivary cotinineSalivary diagnosticsPharmacokineticsTobacco regulatory sciencePersonalized health care |
| spellingShingle | E.C. Hensel R.J. Robinson Feasibility assessment of a pharmaco-kinetic behavior based yield model of salivary cotinine among tobacco users Toxicology Reports Electronic cigarette Salivary cotinine Salivary diagnostics Pharmacokinetics Tobacco regulatory science Personalized health care |
| title | Feasibility assessment of a pharmaco-kinetic behavior based yield model of salivary cotinine among tobacco users |
| title_full | Feasibility assessment of a pharmaco-kinetic behavior based yield model of salivary cotinine among tobacco users |
| title_fullStr | Feasibility assessment of a pharmaco-kinetic behavior based yield model of salivary cotinine among tobacco users |
| title_full_unstemmed | Feasibility assessment of a pharmaco-kinetic behavior based yield model of salivary cotinine among tobacco users |
| title_short | Feasibility assessment of a pharmaco-kinetic behavior based yield model of salivary cotinine among tobacco users |
| title_sort | feasibility assessment of a pharmaco kinetic behavior based yield model of salivary cotinine among tobacco users |
| topic | Electronic cigarette Salivary cotinine Salivary diagnostics Pharmacokinetics Tobacco regulatory science Personalized health care |
| url | http://www.sciencedirect.com/science/article/pii/S2214750025000162 |
| work_keys_str_mv | AT echensel feasibilityassessmentofapharmacokineticbehaviorbasedyieldmodelofsalivarycotinineamongtobaccousers AT rjrobinson feasibilityassessmentofapharmacokineticbehaviorbasedyieldmodelofsalivarycotinineamongtobaccousers |