The role of TNF-α inhibitor in glioma virotherapy: A mathematical model
Virotherapy, using herpes simplex virus, represents a promising therapy of glioma. But the innate immune response, which includes TNF-α produced by macrophages, reduces the effectiveness of the treatment. Hence treatment with TNF-α inhibitor may increase the effectiveness of the virotherapy. In the...
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| Format: | Article |
| Language: | English |
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AIMS Press
2016-12-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2017020 |
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| author | Elzbieta Ratajczyk Urszula Ledzewicz Maciej Leszczynski Avner Friedman |
| author_facet | Elzbieta Ratajczyk Urszula Ledzewicz Maciej Leszczynski Avner Friedman |
| author_sort | Elzbieta Ratajczyk |
| collection | DOAJ |
| description | Virotherapy, using herpes simplex virus, represents a promising therapy of glioma. But the innate immune response, which includes TNF-α produced by macrophages, reduces the effectiveness of the treatment. Hence treatment with TNF-α inhibitor may increase the effectiveness of the virotherapy. In the present paper we develop a mathematical model that includes continuous infusion of the virus in combination with TNF-α inhibitor. We study the efficacy of the treatment under different combinations of the two drugs for different scenarios of the burst size of newly formed virus emerging from dying infected cancer cells. The model may serve as a first step toward developing an optimal strategy for the treatment of glioma by the combination of TNF-α inhibitor and oncolytic virus injection. |
| format | Article |
| id | doaj-art-618f6ea351bf4ddebc33393f6eea25c1 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-618f6ea351bf4ddebc33393f6eea25c12025-01-24T02:39:32ZengAIMS PressMathematical Biosciences and Engineering1551-00182016-12-0114130531910.3934/mbe.2017020The role of TNF-α inhibitor in glioma virotherapy: A mathematical modelElzbieta Ratajczyk0Urszula Ledzewicz1Maciej Leszczynski2Avner Friedman3Institute of Mathematics, Lodz University of Technology, 90-924 Lodz, PolandInstitute of Mathematics, Lodz University of Technology, 90-924 Lodz, PolandInstitute of Mathematics, Lodz University of Technology, 90-924 Lodz, PolandDepartment of Mathematics, The Ohio State University, Columbus, OH 43210, USAVirotherapy, using herpes simplex virus, represents a promising therapy of glioma. But the innate immune response, which includes TNF-α produced by macrophages, reduces the effectiveness of the treatment. Hence treatment with TNF-α inhibitor may increase the effectiveness of the virotherapy. In the present paper we develop a mathematical model that includes continuous infusion of the virus in combination with TNF-α inhibitor. We study the efficacy of the treatment under different combinations of the two drugs for different scenarios of the burst size of newly formed virus emerging from dying infected cancer cells. The model may serve as a first step toward developing an optimal strategy for the treatment of glioma by the combination of TNF-α inhibitor and oncolytic virus injection.https://www.aimspress.com/article/doi/10.3934/mbe.2017020dynamical systemvirotherapytnf-α inhibitorsefficacycombination therapyglioma |
| spellingShingle | Elzbieta Ratajczyk Urszula Ledzewicz Maciej Leszczynski Avner Friedman The role of TNF-α inhibitor in glioma virotherapy: A mathematical model Mathematical Biosciences and Engineering dynamical system virotherapy tnf-α inhibitors efficacy combination therapy glioma |
| title | The role of TNF-α inhibitor in glioma virotherapy: A mathematical model |
| title_full | The role of TNF-α inhibitor in glioma virotherapy: A mathematical model |
| title_fullStr | The role of TNF-α inhibitor in glioma virotherapy: A mathematical model |
| title_full_unstemmed | The role of TNF-α inhibitor in glioma virotherapy: A mathematical model |
| title_short | The role of TNF-α inhibitor in glioma virotherapy: A mathematical model |
| title_sort | role of tnf α inhibitor in glioma virotherapy a mathematical model |
| topic | dynamical system virotherapy tnf-α inhibitors efficacy combination therapy glioma |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2017020 |
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