Improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure: Analysis of the Japan cardiac device treatment registry database
Abstract Background Temporal change in outcomes of heart failure patients receiving cardiac resynchronization therapy with a defibrillator (CRT‐D) is unknown. Methods We assess outcomes and underlying heart diseases of patients receiving CRT‐D with analyzing database of the Japan cardiac device trea...
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Journal of Arrhythmia |
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| Online Access: | https://doi.org/10.1002/joa3.12952 |
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| author | Hisashi Yokoshiki Akihiko Shimizu Takeshi Mitsuhashi Kohei Ishibashi Tomoyuki Kabutoya Yasuhiro Yoshiga Yusuke Kondo Haruhiko Abe Wataru Shimizu Members of the Implantable Cardioverter‐Defibrillator (ICD) Committee of the Japanese Heart Rhythm Society |
| author_facet | Hisashi Yokoshiki Akihiko Shimizu Takeshi Mitsuhashi Kohei Ishibashi Tomoyuki Kabutoya Yasuhiro Yoshiga Yusuke Kondo Haruhiko Abe Wataru Shimizu Members of the Implantable Cardioverter‐Defibrillator (ICD) Committee of the Japanese Heart Rhythm Society |
| author_sort | Hisashi Yokoshiki |
| collection | DOAJ |
| description | Abstract Background Temporal change in outcomes of heart failure patients receiving cardiac resynchronization therapy with a defibrillator (CRT‐D) is unknown. Methods We assess outcomes and underlying heart diseases of patients receiving CRT‐D with analyzing database of the Japan cardiac device treatment registry (JCDTR) at the implantation year 2011–2015 and New JCDTR at the implantation year 2018–2021. Results Proportion of nonischemic heart diseases was about 70% in both the groups (JCDTR: 69%; New JCDTR: 72%). Cardiac sarcoidosis increased with the rate of 5% in the JCDTR to 9% in the New JCDTR group. During an average follow‐up of 21 months, death from any cause occurred in 167 of 906 patients in the JCDTR group (18%) and 79 of 611 patients in the New JCDTR group (13%) (adjusted hazard ratio [aHR] in the New JCDTR group, 0.72; 95% confidence interval [CI]: 0.55–0.94; p = .017). The superiority was mainly driven by reduction in the risk of noncardiac death. With regard to appropriate and inappropriate implantable cardioverter–defibrillator (ICD) therapy, there was a significant reduction in the New JCDTR group versus the JCDTR group (aHR in the New JCDTR group, 0.76; 95% CI: 0.59–0.98; p = .032 for appropriate ICD therapy; aHR in the New JCDTR group, 0.24; 95% CI: 0.12–0.50; p < .0001 for inappropriate ICD therapy). Conclusions All‐cause mortality was reduced in CRT‐D patients implanted during 2018–2021 compared to those during 2011–2015, with a significant reduction in noncardiac death. |
| format | Article |
| id | doaj-art-618d1764d29b4036aa87f86de896ed85 |
| institution | DOAJ |
| issn | 1880-4276 1883-2148 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Wiley |
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| series | Journal of Arrhythmia |
| spelling | doaj-art-618d1764d29b4036aa87f86de896ed852025-08-20T03:12:38ZengWileyJournal of Arrhythmia1880-42761883-21482024-02-01401303710.1002/joa3.12952Improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure: Analysis of the Japan cardiac device treatment registry databaseHisashi Yokoshiki0Akihiko Shimizu1Takeshi Mitsuhashi2Kohei Ishibashi3Tomoyuki Kabutoya4Yasuhiro Yoshiga5Yusuke Kondo6Haruhiko Abe7Wataru Shimizu8Members of the Implantable Cardioverter‐Defibrillator (ICD) Committee of the Japanese Heart Rhythm SocietyDepartment of Cardiovascular Medicine Sapporo City General Hospital Sapporo JapanUBE Kohsan Central Hospital Ube JapanDepartment of Cardiovascular Medicine Hoshi General Hospital Koriyama JapanDepartment of Cardiovascular Medicine National Cerebral and Cardiovascular Center Suita JapanDivision of Cardiovascular Medicine, Department of Medicine Jichi Medical University School of Medicine Shimotsuke JapanDivision of Cardiology, Department of Medicine and Clinical Science Yamaguchi University Graduate School of Medicine Ube JapanDepartment of Cardiovascular Medicine Chiba University Graduate School of Medicine Chiba JapanDepartment of Heart Rhythm Management University of Occupational and Environmental Health Kitakyushu JapanDepartment of Cardiovascular Medicine Nippon Medical School Bunkyo‐ku JapanAbstract Background Temporal change in outcomes of heart failure patients receiving cardiac resynchronization therapy with a defibrillator (CRT‐D) is unknown. Methods We assess outcomes and underlying heart diseases of patients receiving CRT‐D with analyzing database of the Japan cardiac device treatment registry (JCDTR) at the implantation year 2011–2015 and New JCDTR at the implantation year 2018–2021. Results Proportion of nonischemic heart diseases was about 70% in both the groups (JCDTR: 69%; New JCDTR: 72%). Cardiac sarcoidosis increased with the rate of 5% in the JCDTR to 9% in the New JCDTR group. During an average follow‐up of 21 months, death from any cause occurred in 167 of 906 patients in the JCDTR group (18%) and 79 of 611 patients in the New JCDTR group (13%) (adjusted hazard ratio [aHR] in the New JCDTR group, 0.72; 95% confidence interval [CI]: 0.55–0.94; p = .017). The superiority was mainly driven by reduction in the risk of noncardiac death. With regard to appropriate and inappropriate implantable cardioverter–defibrillator (ICD) therapy, there was a significant reduction in the New JCDTR group versus the JCDTR group (aHR in the New JCDTR group, 0.76; 95% CI: 0.59–0.98; p = .032 for appropriate ICD therapy; aHR in the New JCDTR group, 0.24; 95% CI: 0.12–0.50; p < .0001 for inappropriate ICD therapy). Conclusions All‐cause mortality was reduced in CRT‐D patients implanted during 2018–2021 compared to those during 2011–2015, with a significant reduction in noncardiac death.https://doi.org/10.1002/joa3.12952cardiac resynchronization therapy with a defibrillator (CRT‐D)ICD therapyimplantable cardioverter–defibrillator (ICD)systolic heart failurethe Japan cardiac device treatment registry (JCDTR) database |
| spellingShingle | Hisashi Yokoshiki Akihiko Shimizu Takeshi Mitsuhashi Kohei Ishibashi Tomoyuki Kabutoya Yasuhiro Yoshiga Yusuke Kondo Haruhiko Abe Wataru Shimizu Members of the Implantable Cardioverter‐Defibrillator (ICD) Committee of the Japanese Heart Rhythm Society Improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure: Analysis of the Japan cardiac device treatment registry database Journal of Arrhythmia cardiac resynchronization therapy with a defibrillator (CRT‐D) ICD therapy implantable cardioverter–defibrillator (ICD) systolic heart failure the Japan cardiac device treatment registry (JCDTR) database |
| title | Improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure: Analysis of the Japan cardiac device treatment registry database |
| title_full | Improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure: Analysis of the Japan cardiac device treatment registry database |
| title_fullStr | Improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure: Analysis of the Japan cardiac device treatment registry database |
| title_full_unstemmed | Improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure: Analysis of the Japan cardiac device treatment registry database |
| title_short | Improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure: Analysis of the Japan cardiac device treatment registry database |
| title_sort | improved outcomes of cardiac resynchronization therapy with a defibrillator in systolic heart failure analysis of the japan cardiac device treatment registry database |
| topic | cardiac resynchronization therapy with a defibrillator (CRT‐D) ICD therapy implantable cardioverter–defibrillator (ICD) systolic heart failure the Japan cardiac device treatment registry (JCDTR) database |
| url | https://doi.org/10.1002/joa3.12952 |
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