Targeting overexpressed HSPA8 by halofuginone suppresses aberrant proliferation and invasion of rheumatoid arthritis fibroblast-like synoviocytes

Targeting overexpressed HSPA8 by halofuginone suppresses aberrant proliferation and invasion of rheumatoid arthritis fibroblast-like synoviocytes

Rheumatoid arthritis (RA) is a challenging autoimmune disorder characterized by fibroblast-like synoviocyte (FLS)-driven synovitis and joint destruction. Halofuginone (HF), a bioactive derivative of febrifugine isolated from the root of Dichroa febrifuga Lour., exhibits therapeutic potential in RA y...

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Bibliographic Details
Main Authors: Yuanyuan Tang, Han Wu, Ping Yan, Zhangxuan Yue, Zeyu Hu, Xunqi Liao, Yali Wang, Ye Lin, Liqing Li, Xiong Cai
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Pharmacological Research
Subjects:
Rheumatoid arthritis
Fibroblast-like synoviocytes
Halofuginone
HSPA8
Adjuvant-induced arthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825001872
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