Cellular hierarchy framework based on single-cell and bulk RNA sequencing reveals fatty acid metabolic biomarker MYDGF as a therapeutic target for ccRCC

Cellular hierarchy framework based on single-cell and bulk RNA sequencing reveals fatty acid metabolic biomarker MYDGF as a therapeutic target for ccRCC

BackgroundFatty acid metabolism (FAM) reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Nevertheless, the effect of FAM reprogramming on the heterogeneity and prognosis of ccRCC individuals remains insufficiently understood.MethodsWe utilized single-cell sequencing and...

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Bibliographic Details
Main Authors: Ning Wang, Ziyu Xu, Lina Zhang, Yanfang Lu, Yanliang Wang, Lei Yan, Huixia Cao, Limeng Wang, Fengmin Shao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
fatty acid metabolism
ccRCC
MYDGF
ScRNA-seq
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1615601/full
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