Pancreas transplantation in the treatment of diabetes mellitus type 1: modern aspects
Diabetes mellitus is a significant social problem. In the Russian Federation, the prevalence of diabetes type 1 is 340.000 people, 21% of them having diabetic nephropathy, as well as other secondary complications leading to disability and high mortality. There are several options for diabetic patien...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2017-09-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/783 |
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| author | S. V. Gautier S. V. Arzumanov |
| author_facet | S. V. Gautier S. V. Arzumanov |
| author_sort | S. V. Gautier |
| collection | DOAJ |
| description | Diabetes mellitus is a significant social problem. In the Russian Federation, the prevalence of diabetes type 1 is 340.000 people, 21% of them having diabetic nephropathy, as well as other secondary complications leading to disability and high mortality. There are several options for diabetic patients with chronic kidney disease dialysis: kidney transplantation with insulin therapy, simultaneous kidney-pancreas transplant or islet transplant. Good long-term results could be obtained by the whole pancreas and kidney combined transplantation through maximum metabolism recovery comparing to other replacement therapy options. The recipientselection with special attention to the cardiovascular system evaluation is essential to successful transplantation. The proper pancreatic graft assessment needs a wide range of criteria to be analyzed. Integral scores can simplify and systematize the assessment. The choice of preservation technique is important to pancreatic graft ischemia-reperfusion injury minimization. Despite the progress in graft preservation methods, cold storage using University of Wisconsin (UW) solution remains to be the gold standard. The evolution of surgical technique has resulted in utilizing the most physiologic variations of exocrine drainage and venous outflow of the pancreas, so-called portoenteric drainages, which were designed to improve remote metabolic effects and to reduce complications probability. |
| format | Article |
| id | doaj-art-6189ee89b2ef49bb9847a1a670079e37 |
| institution | Kabale University |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2017-09-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-6189ee89b2ef49bb9847a1a670079e372025-08-20T03:59:52ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912017-09-01193708010.15825/1995-1191-2017-3-70-80647Pancreas transplantation in the treatment of diabetes mellitus type 1: modern aspectsS. V. Gautier0S. V. Arzumanov1V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian FederationN.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch of the National Medical Radiological Research Centre of the Ministry of Healthcare of the Russian FederationDiabetes mellitus is a significant social problem. In the Russian Federation, the prevalence of diabetes type 1 is 340.000 people, 21% of them having diabetic nephropathy, as well as other secondary complications leading to disability and high mortality. There are several options for diabetic patients with chronic kidney disease dialysis: kidney transplantation with insulin therapy, simultaneous kidney-pancreas transplant or islet transplant. Good long-term results could be obtained by the whole pancreas and kidney combined transplantation through maximum metabolism recovery comparing to other replacement therapy options. The recipientselection with special attention to the cardiovascular system evaluation is essential to successful transplantation. The proper pancreatic graft assessment needs a wide range of criteria to be analyzed. Integral scores can simplify and systematize the assessment. The choice of preservation technique is important to pancreatic graft ischemia-reperfusion injury minimization. Despite the progress in graft preservation methods, cold storage using University of Wisconsin (UW) solution remains to be the gold standard. The evolution of surgical technique has resulted in utilizing the most physiologic variations of exocrine drainage and venous outflow of the pancreas, so-called portoenteric drainages, which were designed to improve remote metabolic effects and to reduce complications probability.https://journal.transpl.ru/vtio/article/view/783transplantationkidneypancreasimmunosuppressionpreservationischemic reperfusion injuryoperative surgical procedure |
| spellingShingle | S. V. Gautier S. V. Arzumanov Pancreas transplantation in the treatment of diabetes mellitus type 1: modern aspects Вестник трансплантологии и искусственных органов transplantation kidney pancreas immunosuppression preservation ischemic reperfusion injury operative surgical procedure |
| title | Pancreas transplantation in the treatment of diabetes mellitus type 1: modern aspects |
| title_full | Pancreas transplantation in the treatment of diabetes mellitus type 1: modern aspects |
| title_fullStr | Pancreas transplantation in the treatment of diabetes mellitus type 1: modern aspects |
| title_full_unstemmed | Pancreas transplantation in the treatment of diabetes mellitus type 1: modern aspects |
| title_short | Pancreas transplantation in the treatment of diabetes mellitus type 1: modern aspects |
| title_sort | pancreas transplantation in the treatment of diabetes mellitus type 1 modern aspects |
| topic | transplantation kidney pancreas immunosuppression preservation ischemic reperfusion injury operative surgical procedure |
| url | https://journal.transpl.ru/vtio/article/view/783 |
| work_keys_str_mv | AT svgautier pancreastransplantationinthetreatmentofdiabetesmellitustype1modernaspects AT svarzumanov pancreastransplantationinthetreatmentofdiabetesmellitustype1modernaspects |