Metabolically associated fatty liver disease. What is the danger of a "safe" disease? Pathogenesis of cardiovascular complications
Background. Nonalcoholic fatty liver disease is most often a latent disease with absent or mild clinical manifestations. It is usually detected as an incidental finding when transaminase levels are elevated or imaging signs of fatty liver degeneration are detected. The definition of non-alcoholic fa...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Open Systems Publication
2025-02-01
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| Series: | Лечащий Врач |
| Subjects: | |
| Online Access: | https://journal.lvrach.ru/jour/article/view/1354 |
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| Summary: | Background. Nonalcoholic fatty liver disease is most often a latent disease with absent or mild clinical manifestations. It is usually detected as an incidental finding when transaminase levels are elevated or imaging signs of fatty liver degeneration are detected. The definition of non-alcoholic fatty liver disease is based on two main principles – morphological picture of biopsy microscopy, which fully corresponds to the changes of alcoholic hepatosis and the absence of the main etiologic factor – alcohol intake in hepatotoxic doses. The epidemiological burden of hepatic steatosis associated with metabolic dysfunction is constantly increasing worldwide and in all age groups. Non-alcoholic fatty liver disease is not a single disease but a spectrum of conditions that range from mild steatosis to non-alcoholic fatty liver disease with associated fibrosis and possible cirrhosis. High index of suspicion is required in patients with components of metabolic syndrome including diabetes, obesity, dyslipidemia and/or hypertension, since the progression of non-alcoholic fatty liver disease from simple steatosis to cirrhosis and hepatocellular carcinoma increases exponentially in these patients. There is a strong association between non-alcoholic fatty liver disease and cardiovascular diseases, such as hypertension, atherosclerosis, coronary artery disease (CAD) and congestive heart failure. Cardiovascular diseases are the leading cause of death in patients with non-alcoholic fatty liver disease.Results. The article discusses pathogenesis. Understanding the progression of the disease and the specific hepatic and extrahepatic diseases associated with each stage is critical for optimal patient management. Methods for correcting disorders are discussed. One of the most studied drugs in recent decades has been ursodeoxycholic acid, which is of great interest in the treatment of non-alcoholic fatty liver disease in combination with cardiovascular diseases due to its pleiotropic effects. |
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| ISSN: | 1560-5175 2687-1181 |