Unveiling the chemotherapeutic potential of two platinum(IV) complexes in skin cancer: in vitro and in vivo Insights

Unveiling the chemotherapeutic potential of two platinum(IV) complexes in skin cancer: in vitro and in vivo Insights

The present study investigates the chemotherapeutic potential of two platinum (IV) complexes, P-PENT and P-HEX, against skin cancer in vitro and in vivo. Both complexes exhibited potent cytotoxicity against HaCaT-II-4 cells with IC50 values of 0.8 ± 0.08 μM and 1.3 ± 0.16 μM respectively, while demo...

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Bibliographic Details
Main Authors: Amjad Slika, Christina Haydar, Joelle Bou Chacra, Seba Al Alam, Stephanie Mehanna, Anthony Lteif, Maria George Elias, Krishant M. Deo, Robin I. Taleb, Janice R. Aldrich-Wright, Costantine F. Daher
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
Skin cancer
Platinum(IV)
Apoptosis
Selectivity
Chemotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590257124000324
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