Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical study
Abstract Background The reference values of eNO have certain differences among people of different countries and races. We aimed to obtain the reference value of eNO in healthy children and adolescents (6–18 years old) in China and to explore the associations between the reference values with ages,...
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BMC
2024-09-01
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| Series: | Respiratory Research |
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| Online Access: | https://doi.org/10.1186/s12931-024-02938-4 |
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| author | Yazun Liu Hao Zhang Jinrong Wang Yuling Han Chunhong Pan Wenhui Jiang Chunyan Ma Yongsheng Shi Chunmei Jia Yuehua Zhang Ming Li Fei Wang Yanyan Yu Yong Feng Li Liu Aihong Liu Qiaoling Zhang Zhen Long Fuli Dai Yanli Zhang Minghong Ji Dongjun Ma |
| author_facet | Yazun Liu Hao Zhang Jinrong Wang Yuling Han Chunhong Pan Wenhui Jiang Chunyan Ma Yongsheng Shi Chunmei Jia Yuehua Zhang Ming Li Fei Wang Yanyan Yu Yong Feng Li Liu Aihong Liu Qiaoling Zhang Zhen Long Fuli Dai Yanli Zhang Minghong Ji Dongjun Ma |
| author_sort | Yazun Liu |
| collection | DOAJ |
| description | Abstract Background The reference values of eNO have certain differences among people of different countries and races. We aimed to obtain the reference value of eNO in healthy children and adolescents (6–18 years old) in China and to explore the associations between the reference values with ages, gender, heights, BMI, and regions. Methods We measured FeNO50 levels in 5949 healthy Chinese children and adolescents, FeNO200 and CaNO levels in 658 participants from 16 provinces of 7 administrative areas in China aged 6–18. All persons were studied after obtaining informed consent from children and their parents. Results The mean FeNO50 of 5949 Chinese children and adolescents aged 6–18 years was 14.1 ppb, with a 95% confidence interval of 1-38.1 ppb. The mean FeNO200 of 658 persons was 6.9 ppb with a 95% upper confidence interval of 15.0 ppb, and the mean CaNO was 3.0 ppb with a 95% upper confidence interval of 11.2 ppb. In the 6–11 age group, age and height were correlated with the logarithm of FeNO50 (P < 0.001, P < 0.05). There was no significant correlation between the logarithm of FeNO200 and gender, age, height and BMI (all P > 0.05). The logarithm of CaNO was correlated with gender (P < 0.05). In the 12–18 age group, gender, height, and region were correlated with the logarithm of FeNO50 (all P < 0.001). There was only a weak correlation between the logarithm of FeNO200 and height (P < 0.001). The logarithm of CaNO was negatively correlated with age (P < 0.05). Conclusions Higher FeNO50, FeNO200 and CaNO values were found in healthy children and adolescents in China compared with foreign reports, and is affected by age, height, gender, and region. This study provides useful references for clinical application of eNO in children, especially Asian children. |
| format | Article |
| id | doaj-art-617f7575b79c4fa984f90a4cded5e906 |
| institution | OA Journals |
| issn | 1465-993X |
| language | English |
| publishDate | 2024-09-01 |
| publisher | BMC |
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| series | Respiratory Research |
| spelling | doaj-art-617f7575b79c4fa984f90a4cded5e9062025-08-20T02:17:58ZengBMCRespiratory Research1465-993X2024-09-0125111410.1186/s12931-024-02938-4Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical studyYazun Liu0Hao Zhang1Jinrong Wang2Yuling Han3Chunhong Pan4Wenhui Jiang5Chunyan Ma6Yongsheng Shi7Chunmei Jia8Yuehua Zhang9Ming Li10Fei Wang11Yanyan Yu12Yong Feng13Li Liu14Aihong Liu15Qiaoling Zhang16Zhen Long17Fuli Dai18Yanli Zhang19Minghong Ji20Dongjun Ma21Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineOutpatient Emergency Department of Shanghai Children’s Medical CenterDepartment of Pediatric Respiratory, Affiliated Provincial Hospital of Shandong First Medical UniversityDepartment of Respiratory, Qilu Children’s Hospital of Shandong UniversityDepartment of Respiratory Medicine, Shanghai Children’s Medical CenterDepartment of Respiratory, Guangzhou Women and Children’s Medical CenterDepartment of Pediatrics, Inner Mongolia People’s HospitalDepartment of Pediatric Respiratory Medicine, Maternity and Child-Care Hospital of Gansu ProvinceDepartment of Pediatrics, the Fourth Hospital of BaotouDepartment of Pediatric Infectious Disease, The Affiliated Haikou Hospital of Xiangya Medical College, Central South UniversityDepartment of Respiration, Kunming Children’s HospitalDepartment of Respiratory, Maternal and Child Health Care Hospital of Guiyang, Children’s Hospital of GuiyangDepartment of Pediatric Asthma, Lianyungang Maternal and Child Health HospitalDepartment of Pediatric Respiratory Medicine, Shengjing Hospital of China Medical UniversityThe First Department of Pediatric Respiratory, The First Hospital of Jilin UniversityDepartment of Respiratory, Children’s Hospital of ShanxiDepartment of Pediatrics, Inner Mongolia Maternity and Child Health Care HospitalDepartment of Pediatric Respiratory Medicine, Tongji Medical College, Maternal and Child Health Hospital of Hubei Province, Huazhong University of Science and TechnologySecond Department of Pediatrics, Luoyang Maternal and Child Health Care HospitalDepartment of Pediatric Respiratory, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Pediatrics, The First Affiliated Hospital of University of Science and Technology of ChinaDepartment of Allergy, Children’s Hospital of UrumqiAbstract Background The reference values of eNO have certain differences among people of different countries and races. We aimed to obtain the reference value of eNO in healthy children and adolescents (6–18 years old) in China and to explore the associations between the reference values with ages, gender, heights, BMI, and regions. Methods We measured FeNO50 levels in 5949 healthy Chinese children and adolescents, FeNO200 and CaNO levels in 658 participants from 16 provinces of 7 administrative areas in China aged 6–18. All persons were studied after obtaining informed consent from children and their parents. Results The mean FeNO50 of 5949 Chinese children and adolescents aged 6–18 years was 14.1 ppb, with a 95% confidence interval of 1-38.1 ppb. The mean FeNO200 of 658 persons was 6.9 ppb with a 95% upper confidence interval of 15.0 ppb, and the mean CaNO was 3.0 ppb with a 95% upper confidence interval of 11.2 ppb. In the 6–11 age group, age and height were correlated with the logarithm of FeNO50 (P < 0.001, P < 0.05). There was no significant correlation between the logarithm of FeNO200 and gender, age, height and BMI (all P > 0.05). The logarithm of CaNO was correlated with gender (P < 0.05). In the 12–18 age group, gender, height, and region were correlated with the logarithm of FeNO50 (all P < 0.001). There was only a weak correlation between the logarithm of FeNO200 and height (P < 0.001). The logarithm of CaNO was negatively correlated with age (P < 0.05). Conclusions Higher FeNO50, FeNO200 and CaNO values were found in healthy children and adolescents in China compared with foreign reports, and is affected by age, height, gender, and region. This study provides useful references for clinical application of eNO in children, especially Asian children.https://doi.org/10.1186/s12931-024-02938-4FeNO50FeNO200CaNOReference valuesChildren and adolescents |
| spellingShingle | Yazun Liu Hao Zhang Jinrong Wang Yuling Han Chunhong Pan Wenhui Jiang Chunyan Ma Yongsheng Shi Chunmei Jia Yuehua Zhang Ming Li Fei Wang Yanyan Yu Yong Feng Li Liu Aihong Liu Qiaoling Zhang Zhen Long Fuli Dai Yanli Zhang Minghong Ji Dongjun Ma Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical study Respiratory Research FeNO50 FeNO200 CaNO Reference values Children and adolescents |
| title | Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical study |
| title_full | Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical study |
| title_fullStr | Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical study |
| title_full_unstemmed | Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical study |
| title_short | Reference values for exhaled nitric oxide in healthy children aged 6–18 years in China: a cross-sectional, multicenter clinical study |
| title_sort | reference values for exhaled nitric oxide in healthy children aged 6 18 years in china a cross sectional multicenter clinical study |
| topic | FeNO50 FeNO200 CaNO Reference values Children and adolescents |
| url | https://doi.org/10.1186/s12931-024-02938-4 |
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