Thromboelastography parameters in chronic viral liver disease and liver resection: a retrospective study
Introduction: Thromboelastography (TEG) provides a global assessment of haemostasis and is potentially applicable to liver disease. The present study aimed to explore the utility of TEG for the evaluation of patients with chronic viral liver disease, which has previously not been investigated. Metho...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2024-08-01
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| Series: | Singapore Medical Journal |
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| Online Access: | https://journals.lww.com/10.4103/singaporemedj.SMJ-2021-404 |
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| author | Ying Di Jialu Li Chunjuan Ye Zheng Wang Qianqian Zhu |
| author_facet | Ying Di Jialu Li Chunjuan Ye Zheng Wang Qianqian Zhu |
| author_sort | Ying Di |
| collection | DOAJ |
| description | Introduction:
Thromboelastography (TEG) provides a global assessment of haemostasis and is potentially applicable to liver disease. The present study aimed to explore the utility of TEG for the evaluation of patients with chronic viral liver disease, which has previously not been investigated.
Methods:
Demographic characteristics and TEG parameters were collected before surgery. Child–Turcotte–Pugh (CTP) and model for end-stage liver disease (MELD) scores were used to categorise stages of liver cirrhosis. Liver resections were classified as low, medium and high complexity.
Results:
A total of 344 patients were included. Results showed significantly longer K-time, smaller α-angle and lower maximum amplitude (MA) with increasing liver disease severity as measured by the CTP and MELD scores (P < 0.05 for all). After multivariable adjustment (including age, sex, liver disease aetiology, alanine aminotransferase [ALT], aspartate aminotransferase [AST], albumin, total bilirubin, haemoglobin and platelet count), TEG parameters (except R-times) were either weakly or inversely related to the severity of liver disease as defined by the MELD score (absolute r < 0.2 and P < 0.05 for all except R-times). R-times obtained before surgery were weakly correlated with perioperative blood loss (r < 0.2 and P < 0.05 for all).
Conclusions:
The correlation between TEG parameters and severity of liver disease was weak. In addition, R-times obtained before liver resection were weakly associated with perioperative blood loss after multivariable adjustments. TEG utility for haemostasis assessment and prediction of blood loss during liver resection should be further explored in high-quality studies. |
| format | Article |
| id | doaj-art-617b3d431c5c4b518f7a72bfa855a0af |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-617b3d431c5c4b518f7a72bfa855a0af2025-02-09T10:23:48ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352024-08-0165843844310.4103/singaporemedj.SMJ-2021-404Thromboelastography parameters in chronic viral liver disease and liver resection: a retrospective studyYing DiJialu LiChunjuan YeZheng WangQianqian ZhuIntroduction: Thromboelastography (TEG) provides a global assessment of haemostasis and is potentially applicable to liver disease. The present study aimed to explore the utility of TEG for the evaluation of patients with chronic viral liver disease, which has previously not been investigated. Methods: Demographic characteristics and TEG parameters were collected before surgery. Child–Turcotte–Pugh (CTP) and model for end-stage liver disease (MELD) scores were used to categorise stages of liver cirrhosis. Liver resections were classified as low, medium and high complexity. Results: A total of 344 patients were included. Results showed significantly longer K-time, smaller α-angle and lower maximum amplitude (MA) with increasing liver disease severity as measured by the CTP and MELD scores (P < 0.05 for all). After multivariable adjustment (including age, sex, liver disease aetiology, alanine aminotransferase [ALT], aspartate aminotransferase [AST], albumin, total bilirubin, haemoglobin and platelet count), TEG parameters (except R-times) were either weakly or inversely related to the severity of liver disease as defined by the MELD score (absolute r < 0.2 and P < 0.05 for all except R-times). R-times obtained before surgery were weakly correlated with perioperative blood loss (r < 0.2 and P < 0.05 for all). Conclusions: The correlation between TEG parameters and severity of liver disease was weak. In addition, R-times obtained before liver resection were weakly associated with perioperative blood loss after multivariable adjustments. TEG utility for haemostasis assessment and prediction of blood loss during liver resection should be further explored in high-quality studies.https://journals.lww.com/10.4103/singaporemedj.SMJ-2021-404chronic viral liver diseaseliver resectionsthromboelastography |
| spellingShingle | Ying Di Jialu Li Chunjuan Ye Zheng Wang Qianqian Zhu Thromboelastography parameters in chronic viral liver disease and liver resection: a retrospective study Singapore Medical Journal chronic viral liver disease liver resections thromboelastography |
| title | Thromboelastography parameters in chronic viral liver disease and liver resection: a retrospective study |
| title_full | Thromboelastography parameters in chronic viral liver disease and liver resection: a retrospective study |
| title_fullStr | Thromboelastography parameters in chronic viral liver disease and liver resection: a retrospective study |
| title_full_unstemmed | Thromboelastography parameters in chronic viral liver disease and liver resection: a retrospective study |
| title_short | Thromboelastography parameters in chronic viral liver disease and liver resection: a retrospective study |
| title_sort | thromboelastography parameters in chronic viral liver disease and liver resection a retrospective study |
| topic | chronic viral liver disease liver resections thromboelastography |
| url | https://journals.lww.com/10.4103/singaporemedj.SMJ-2021-404 |
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