Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults
Studies have shown that low forced vital capacity (LFVC) is associated with atherosclerosis. However, it is unclear whether LFVC is associated with resting electrocardiographic ST-T abnormalities, a common finding that is prognostic for cardiovascular events. Therefore, pulmonary functions, ST-T abn...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/460398 |
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| author | Kei Nakajima Yulan Li Hiroshi Fuchigami Hiromi Munakata |
| author_facet | Kei Nakajima Yulan Li Hiroshi Fuchigami Hiromi Munakata |
| author_sort | Kei Nakajima |
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| description | Studies have shown that low forced vital capacity (LFVC) is associated with atherosclerosis. However, it is unclear whether LFVC is associated with resting electrocardiographic ST-T abnormalities, a common finding that is prognostic for cardiovascular events. Therefore, pulmonary functions, ST-T abnormalities defined with Minnesota Code, and cardiometabolic risk factors were examined in a cross-sectional study of 1,653 asymptomatic adults without past history of coronary heart diseases. The prevalence of diabetes, metabolic syndrome, and ST-T abnormalities significantly increased with decreasing percent of predicted forced vital capacity (%PFVC). ST-T abnormalities were observed in 73 subjects (4.4% in total). Multiple logistic regression analysis showed that, compared with the highest quartile of %PFVC (≥99.7%), the lowest quartile of %PFVC (≤84.2%) was persistently associated with ST-T abnormalities even after further adjustment for diabetes or metabolic syndrome (odds ratio (95%CI): 2.44 (1.16–5.14) and 2.42 (1.15–5.10), resp.). Similar trends were observed when subjects were divided into quartiles according to percent of predicted forced expiratory volume in 1 second (FEV1), but not the ratio of FEV1/FVC. In conclusion, LFVC may be associated with ST-T abnormalities independent of metabolic abnormalities in asymptomatic adults, suggesting a plausible link between impaired pulmonary defects and cardiovascular diseases. |
| format | Article |
| id | doaj-art-617ac95732d740af888e307f5bbc593d |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-617ac95732d740af888e307f5bbc593d2025-02-03T01:00:37ZengWileyPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/460398460398Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic AdultsKei Nakajima0Yulan Li1Hiroshi Fuchigami2Hiromi Munakata3Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, JapanDivision of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, JapanDepartment of Health Care Center, Social Insurance Omiya General Hospital, 453 Bonsai, Kita, Saitama 331-0805, JapanDepartment of Internal Medicine, Social Insurance Omiya General Hospital, 453 Bonsai, Kita, Saitama 331-0805, JapanStudies have shown that low forced vital capacity (LFVC) is associated with atherosclerosis. However, it is unclear whether LFVC is associated with resting electrocardiographic ST-T abnormalities, a common finding that is prognostic for cardiovascular events. Therefore, pulmonary functions, ST-T abnormalities defined with Minnesota Code, and cardiometabolic risk factors were examined in a cross-sectional study of 1,653 asymptomatic adults without past history of coronary heart diseases. The prevalence of diabetes, metabolic syndrome, and ST-T abnormalities significantly increased with decreasing percent of predicted forced vital capacity (%PFVC). ST-T abnormalities were observed in 73 subjects (4.4% in total). Multiple logistic regression analysis showed that, compared with the highest quartile of %PFVC (≥99.7%), the lowest quartile of %PFVC (≤84.2%) was persistently associated with ST-T abnormalities even after further adjustment for diabetes or metabolic syndrome (odds ratio (95%CI): 2.44 (1.16–5.14) and 2.42 (1.15–5.10), resp.). Similar trends were observed when subjects were divided into quartiles according to percent of predicted forced expiratory volume in 1 second (FEV1), but not the ratio of FEV1/FVC. In conclusion, LFVC may be associated with ST-T abnormalities independent of metabolic abnormalities in asymptomatic adults, suggesting a plausible link between impaired pulmonary defects and cardiovascular diseases.http://dx.doi.org/10.1155/2012/460398 |
| spellingShingle | Kei Nakajima Yulan Li Hiroshi Fuchigami Hiromi Munakata Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults Pulmonary Medicine |
| title | Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults |
| title_full | Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults |
| title_fullStr | Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults |
| title_full_unstemmed | Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults |
| title_short | Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults |
| title_sort | low vital capacity and electrocardiographic st t abnormalities in asymptomatic adults |
| url | http://dx.doi.org/10.1155/2012/460398 |
| work_keys_str_mv | AT keinakajima lowvitalcapacityandelectrocardiographicsttabnormalitiesinasymptomaticadults AT yulanli lowvitalcapacityandelectrocardiographicsttabnormalitiesinasymptomaticadults AT hiroshifuchigami lowvitalcapacityandelectrocardiographicsttabnormalitiesinasymptomaticadults AT hiromimunakata lowvitalcapacityandelectrocardiographicsttabnormalitiesinasymptomaticadults |