Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia.
<h4>Objective</h4>Studies on children with Acute Lymphoblastic Leukemia (ALL) reported non-adherence in 2-54% of cases. The primary objective of this study was to assess rates of adherence to 6-MP using two different methods in children and adolescents with ALL. Secondary aim was to iden...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0183119&type=printable |
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| author | Mervat Alsous Rana Abu Farha Eman Alefishat Suha Al Omar Deema Momani Alia Gharabli James McElnay Robert Horne Rawad Rihani |
| author_facet | Mervat Alsous Rana Abu Farha Eman Alefishat Suha Al Omar Deema Momani Alia Gharabli James McElnay Robert Horne Rawad Rihani |
| author_sort | Mervat Alsous |
| collection | DOAJ |
| description | <h4>Objective</h4>Studies on children with Acute Lymphoblastic Leukemia (ALL) reported non-adherence in 2-54% of cases. The primary objective of this study was to assess rates of adherence to 6-MP using two different methods in children and adolescents with ALL. Secondary aim was to identify factors that influence adherence to 6-MP in children with ALL.<h4>Methods</h4>All eligible children with ALL who are (≤ 19) years old and receive 6-MP therapy for at least 1 month were approached to participate in the study. A total of 52 children with ALL and their primary caregivers were recruited. Adherence measures included an objective method (measuring 6-MP metabolites in packed Red Blood Cells (RBCs)) and a subjective method (using parent and child self-report via the Medication Adherence Report Scale; MARS; Adherence was defined as 90% or greater).<h4>Results</h4>Rates of adherence varied across the measurement methods. Packed RBCs sample analysis indicated forty-four patients (84.6%) to be adherent. Using the MARS questionnaires, a total of 49 children (94.2%) were classified as being adherent according to the parental MARS questionnaire scores, while all the 15 children (100%) who answered the MARS (child) questionnaire were classified as adherent. Overall adherence rate was 80.8% within the studied population.<h4>Conclusion</h4>MARS scale was shown to overestimate adherence compared to measurement of 6-MP metabolites in the blood. A combination of both methods led to increased detection of non-adherence to thiopurine in children with ALL. |
| format | Article |
| id | doaj-art-6177a3ac547f4de3b3cf4a9b9b140bb0 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-6177a3ac547f4de3b3cf4a9b9b140bb02025-08-20T02:03:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018311910.1371/journal.pone.0183119Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia.Mervat AlsousRana Abu FarhaEman AlefishatSuha Al OmarDeema MomaniAlia GharabliJames McElnayRobert HorneRawad Rihani<h4>Objective</h4>Studies on children with Acute Lymphoblastic Leukemia (ALL) reported non-adherence in 2-54% of cases. The primary objective of this study was to assess rates of adherence to 6-MP using two different methods in children and adolescents with ALL. Secondary aim was to identify factors that influence adherence to 6-MP in children with ALL.<h4>Methods</h4>All eligible children with ALL who are (≤ 19) years old and receive 6-MP therapy for at least 1 month were approached to participate in the study. A total of 52 children with ALL and their primary caregivers were recruited. Adherence measures included an objective method (measuring 6-MP metabolites in packed Red Blood Cells (RBCs)) and a subjective method (using parent and child self-report via the Medication Adherence Report Scale; MARS; Adherence was defined as 90% or greater).<h4>Results</h4>Rates of adherence varied across the measurement methods. Packed RBCs sample analysis indicated forty-four patients (84.6%) to be adherent. Using the MARS questionnaires, a total of 49 children (94.2%) were classified as being adherent according to the parental MARS questionnaire scores, while all the 15 children (100%) who answered the MARS (child) questionnaire were classified as adherent. Overall adherence rate was 80.8% within the studied population.<h4>Conclusion</h4>MARS scale was shown to overestimate adherence compared to measurement of 6-MP metabolites in the blood. A combination of both methods led to increased detection of non-adherence to thiopurine in children with ALL.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0183119&type=printable |
| spellingShingle | Mervat Alsous Rana Abu Farha Eman Alefishat Suha Al Omar Deema Momani Alia Gharabli James McElnay Robert Horne Rawad Rihani Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia. PLoS ONE |
| title | Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia. |
| title_full | Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia. |
| title_fullStr | Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia. |
| title_full_unstemmed | Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia. |
| title_short | Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia. |
| title_sort | adherence to 6 mercaptopurine in children and adolescents with acute lymphoblastic leukemia |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0183119&type=printable |
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