Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis

Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis

Abstract Background Fibrosis and inflammation in the renal tubular epithelial cells (TECs) are key contributors to the pathology of diabetic kidney disease (DKD). Nevertheless, the precise triggers of these processes remain unclear. This study aimed to explore the role of interferon‐stimulated gene...

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Bibliographic Details
Main Authors: Lingzhi Huang, Xinyi Chen, Yawen Shao, Shujun Deng, Chen Wang, Jianqiao Chen, Yongsheng Xie, Siming Yuan, Liqin Tang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Clinical and Translational Medicine
Subjects:
diabetic kidney disease
fibrosis
ISG15
pyroptosis
renal tubular epithelial cells
Online Access:https://doi.org/10.1002/ctm2.70337
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