Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study
To study the brain functional alterations of children after spinal cord injury (SCI) and explore their changes after motor imagery training (MIT), revealing brain functional reorganizations in pediatric SCI and finding possible neural mechanisms of MIT. Thirty pediatric SCI patients and 30 age- and...
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| Language: | English |
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Elsevier
2025-12-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242125001198 |
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| author | Ling Wang Beining Yang Qunya Qi Haotian Xin Yu Wang Yulong Jia Qian Chen Weimin Zheng Xin Chen Tengfei Liang Chuchu Sun Jubao Du Baowei Li Jie Lu Nan Chen |
| author_facet | Ling Wang Beining Yang Qunya Qi Haotian Xin Yu Wang Yulong Jia Qian Chen Weimin Zheng Xin Chen Tengfei Liang Chuchu Sun Jubao Du Baowei Li Jie Lu Nan Chen |
| author_sort | Ling Wang |
| collection | DOAJ |
| description | To study the brain functional alterations of children after spinal cord injury (SCI) and explore their changes after motor imagery training (MIT), revealing brain functional reorganizations in pediatric SCI and finding possible neural mechanisms of MIT. Thirty pediatric SCI patients and 30 age- and gender-matched healthy controls (HCs) were recruited. Brain resting-state functional MRI images of all subjects were obtained using a 3.0 Tesla MRI system. Subsequently, eight of the patients completed a 4-week MIT, and then functional MRI scans were conducted once again. Then two-sample t-tests were used to compare amplitude of low frequency (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) between groups at baseline, and paired t-tests were used to investigate the changes in ALFF, fALFF and ReHo of patients before and after the treatment. Compared with HCs, the patients showed decreased ALFF and/or ReHo in bilateral postcentral gyrus (S1) and right orbitofrontal cortex, while increased ALFF and/or ReHo in the bilateral cerebellar lobules IV-VI, thalamus, left middle cingulate cortex (MCC), cerebellar Crus II, and right parahippocampal gyrus, caudate nucleus, middle temporal gyrus (MTG). Compared with those before MIT, the patients showed significantly increased ALFF in the right S1 after the treatment. These findings demonstrated brain functional reorganization in sensoriomotor, cognitive-emotional and auditory/language related regions, and MIT may promote the rehabilitation by reversing the functionally reorganized sensoriomotor areas, which may provide a possible mechanism for MIT. |
| format | Article |
| id | doaj-art-616c6ec82a1a4738b07e2fd43f82b072 |
| institution | Kabale University |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj-art-616c6ec82a1a4738b07e2fd43f82b0722025-08-20T03:36:52ZengElsevierIBRO Neuroscience Reports2667-24212025-12-011939139910.1016/j.ibneur.2025.08.003Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary studyLing Wang0Beining Yang1Qunya Qi2Haotian Xin3Yu Wang4Yulong Jia5Qian Chen6Weimin Zheng7Xin Chen8Tengfei Liang9Chuchu Sun10Jubao Du11Baowei Li12Jie Lu13Nan Chen14Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, ChinaDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, ChinaDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, ChinaDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, ChinaDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, ChinaDepartment of Medical Imaging, Affiliated Hospital of Hebei Engineering University, Handan, ChinaDepartment of Nuclear Medicine, Beijing Electric Power Hospital, Beijing, ChinaDepartment of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Medical Imaging, Affiliated Hospital of Hebei Engineering University, Handan, ChinaDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, ChinaDepartment of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China; Correspondence to: Department of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, No. 45 Chang-chun St, Xicheng District, Beijing, China.To study the brain functional alterations of children after spinal cord injury (SCI) and explore their changes after motor imagery training (MIT), revealing brain functional reorganizations in pediatric SCI and finding possible neural mechanisms of MIT. Thirty pediatric SCI patients and 30 age- and gender-matched healthy controls (HCs) were recruited. Brain resting-state functional MRI images of all subjects were obtained using a 3.0 Tesla MRI system. Subsequently, eight of the patients completed a 4-week MIT, and then functional MRI scans were conducted once again. Then two-sample t-tests were used to compare amplitude of low frequency (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) between groups at baseline, and paired t-tests were used to investigate the changes in ALFF, fALFF and ReHo of patients before and after the treatment. Compared with HCs, the patients showed decreased ALFF and/or ReHo in bilateral postcentral gyrus (S1) and right orbitofrontal cortex, while increased ALFF and/or ReHo in the bilateral cerebellar lobules IV-VI, thalamus, left middle cingulate cortex (MCC), cerebellar Crus II, and right parahippocampal gyrus, caudate nucleus, middle temporal gyrus (MTG). Compared with those before MIT, the patients showed significantly increased ALFF in the right S1 after the treatment. These findings demonstrated brain functional reorganization in sensoriomotor, cognitive-emotional and auditory/language related regions, and MIT may promote the rehabilitation by reversing the functionally reorganized sensoriomotor areas, which may provide a possible mechanism for MIT.http://www.sciencedirect.com/science/article/pii/S2667242125001198PediatricSpinal cord injuryMagnetic resonance imagingBrain functional reorganizationMotor imagery training |
| spellingShingle | Ling Wang Beining Yang Qunya Qi Haotian Xin Yu Wang Yulong Jia Qian Chen Weimin Zheng Xin Chen Tengfei Liang Chuchu Sun Jubao Du Baowei Li Jie Lu Nan Chen Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study IBRO Neuroscience Reports Pediatric Spinal cord injury Magnetic resonance imaging Brain functional reorganization Motor imagery training |
| title | Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study |
| title_full | Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study |
| title_fullStr | Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study |
| title_full_unstemmed | Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study |
| title_short | Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study |
| title_sort | brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it a preliminary study |
| topic | Pediatric Spinal cord injury Magnetic resonance imaging Brain functional reorganization Motor imagery training |
| url | http://www.sciencedirect.com/science/article/pii/S2667242125001198 |
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