The In Silico Optimization of a Fed-Batch Reactor Used for the Enzymatic Hydrolysis of Chicory Inulin to Fructose by Employing a Dynamic Approach
In recent years, inulin enzymatic hydrolysis has become a very promising alternative for producing fructose on a large scale. Genetically modified chicory was used to extract inulin of industrial quality. By using an adequate kinetic model from the literature, this study aimed to determine the optim...
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MDPI AG
2025-03-01
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| Series: | Dynamics |
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| author | Daniela Gheorghe Gheorghe Maria Laura Renea Crina Muscalu |
| author_facet | Daniela Gheorghe Gheorghe Maria Laura Renea Crina Muscalu |
| author_sort | Daniela Gheorghe |
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| description | In recent years, inulin enzymatic hydrolysis has become a very promising alternative for producing fructose on a large scale. Genetically modified chicory was used to extract inulin of industrial quality. By using an adequate kinetic model from the literature, this study aimed to determine the optimal operating alternatives of a batch (<b>BR</b>) or fed-batch (<b>FBR</b>) reactor used for the hydrolysis of inulin to fructose. The operation of the <b>FBR</b> with a constant or variable/dynamic feeding was compared to that of the <b>BR</b> to determine which best maximizes reactor production while minimizing enzyme consumption. Multi-objective optimal solutions were also investigated by using the Pareto-optimal front technique. Our in-silico analysis reveals that, for this enzymatic process, the best alternative is the <b>FBR</b> operated with a constant control variable but using the set-point given by the (breakpoint) of the Pareto optimal front under the imposed technological constraints. This set point reported the best performances, regarding all the considered opposite economic objectives. Also, the <b>FBR</b> with a constant, but NLP optimal feeding, reported fairly good performances. |
| format | Article |
| id | doaj-art-615de936861b4ce3a5693f9bc56c70f4 |
| institution | DOAJ |
| issn | 2673-8716 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Dynamics |
| spelling | doaj-art-615de936861b4ce3a5693f9bc56c70f42025-08-20T02:42:40ZengMDPI AGDynamics2673-87162025-03-01511010.3390/dynamics5010010The In Silico Optimization of a Fed-Batch Reactor Used for the Enzymatic Hydrolysis of Chicory Inulin to Fructose by Employing a Dynamic ApproachDaniela Gheorghe0Gheorghe Maria1Laura Renea2Crina Muscalu3Department of Chemical and Biochemical Engineering, University Politehnica of Bucharest, Str. G. Polizu 1-7, 011061 Bucharest, RomaniaDepartment of Chemical and Biochemical Engineering, University Politehnica of Bucharest, Str. G. Polizu 1-7, 011061 Bucharest, RomaniaDepartment of Chemical and Biochemical Engineering, University Politehnica of Bucharest, Str. G. Polizu 1-7, 011061 Bucharest, RomaniaDepartment of Chemical and Biochemical Engineering, University Politehnica of Bucharest, Str. G. Polizu 1-7, 011061 Bucharest, RomaniaIn recent years, inulin enzymatic hydrolysis has become a very promising alternative for producing fructose on a large scale. Genetically modified chicory was used to extract inulin of industrial quality. By using an adequate kinetic model from the literature, this study aimed to determine the optimal operating alternatives of a batch (<b>BR</b>) or fed-batch (<b>FBR</b>) reactor used for the hydrolysis of inulin to fructose. The operation of the <b>FBR</b> with a constant or variable/dynamic feeding was compared to that of the <b>BR</b> to determine which best maximizes reactor production while minimizing enzyme consumption. Multi-objective optimal solutions were also investigated by using the Pareto-optimal front technique. Our in-silico analysis reveals that, for this enzymatic process, the best alternative is the <b>FBR</b> operated with a constant control variable but using the set-point given by the (breakpoint) of the Pareto optimal front under the imposed technological constraints. This set point reported the best performances, regarding all the considered opposite economic objectives. Also, the <b>FBR</b> with a constant, but NLP optimal feeding, reported fairly good performances.https://www.mdpi.com/2673-8716/5/1/10inulin hydrolysis to fructosefed-batch reactorproduction maximizationin-silico analysisPareto fronts |
| spellingShingle | Daniela Gheorghe Gheorghe Maria Laura Renea Crina Muscalu The In Silico Optimization of a Fed-Batch Reactor Used for the Enzymatic Hydrolysis of Chicory Inulin to Fructose by Employing a Dynamic Approach Dynamics inulin hydrolysis to fructose fed-batch reactor production maximization in-silico analysis Pareto fronts |
| title | The In Silico Optimization of a Fed-Batch Reactor Used for the Enzymatic Hydrolysis of Chicory Inulin to Fructose by Employing a Dynamic Approach |
| title_full | The In Silico Optimization of a Fed-Batch Reactor Used for the Enzymatic Hydrolysis of Chicory Inulin to Fructose by Employing a Dynamic Approach |
| title_fullStr | The In Silico Optimization of a Fed-Batch Reactor Used for the Enzymatic Hydrolysis of Chicory Inulin to Fructose by Employing a Dynamic Approach |
| title_full_unstemmed | The In Silico Optimization of a Fed-Batch Reactor Used for the Enzymatic Hydrolysis of Chicory Inulin to Fructose by Employing a Dynamic Approach |
| title_short | The In Silico Optimization of a Fed-Batch Reactor Used for the Enzymatic Hydrolysis of Chicory Inulin to Fructose by Employing a Dynamic Approach |
| title_sort | in silico optimization of a fed batch reactor used for the enzymatic hydrolysis of chicory inulin to fructose by employing a dynamic approach |
| topic | inulin hydrolysis to fructose fed-batch reactor production maximization in-silico analysis Pareto fronts |
| url | https://www.mdpi.com/2673-8716/5/1/10 |
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