HAX1, gene responsible for Kostmann syndrome, regulates gingival epithelial barrier function via intracellular trafficking of JAM1

HAX1, gene responsible for Kostmann syndrome, regulates gingival epithelial barrier function via intracellular trafficking of JAM1

BackgroundKostmann syndrome is an autosomal recessive disorder caused by a mutation of the hematopoietic cell-specific Lyn substrate 1 associated protein X-1 (HAX1) gene, and characterized by low number of neutrophils and increased susceptibility to infections. Additionally, Kostmann syndrome is kno...

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Main Authors: Keita Tanigaki, Tsukasa Tamamori, Naoko Sasaki, Risako Matsumura, Shunsuke Yamaga, Akito Sakanaka, Atsuo Amano, Michiya Matsusaki, Hiroki Takeuchi, Masae Kuboniwa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HAX1
JAM1
Kostmann syndrome
cisplatin
periodontitis
barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1624718/full
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