PROMISE: Prognostic Radiomic Outcome Measurement in Acute Subdural Hematoma Evacuation Post-Craniotomy
<b>Background/Objectives:</b> Traumatic acute subdural hematoma (aSDH) often requires surgical intervention, such as craniotomy, to relieve mass lesions and pressure. The extent of hematoma evacuation significantly impacts patient outcomes. This study utilizes 3D Slicer software to analy...
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2025-01-01
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| author | Alexandru Guranda Antonia Richter Johannes Wach Erdem Güresir Martin Vychopen |
| author_facet | Alexandru Guranda Antonia Richter Johannes Wach Erdem Güresir Martin Vychopen |
| author_sort | Alexandru Guranda |
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| description | <b>Background/Objectives:</b> Traumatic acute subdural hematoma (aSDH) often requires surgical intervention, such as craniotomy, to relieve mass lesions and pressure. The extent of hematoma evacuation significantly impacts patient outcomes. This study utilizes 3D Slicer software to analyse post-craniotomy hematoma volume changes and evaluate their prognostic significance in aSDH patients. <b>Methods:</b> Among 178 adult patients diagnosed with aSDH from January 2015 to December 2022, 64 underwent hematoma evacuation via craniotomy. Initial scans were performed within 24 h of trauma, followed by routine postoperative scans to assess residual hematoma. We conducted radiomic analysis of preoperative and postoperative volumes, surface area, Feret diameter, sphericity, flatness, and elongation. Clinical parameters, including SOFA score, APACHE score, pupillary response, comorbidities, age, anticoagulation status, and preoperative haematocrit and haemoglobin levels, were also evaluated. <b>Results:</b> Changes in Δ surface area significantly correlated with 30-day outcomes (<i>p</i> = 0.03) and showed moderate predictive accuracy (AUC = 0.65). Patients with a Δ surface area > 30,090 mm<sup>2</sup> experienced poorer outcomes (OR = 6.66, <i>p</i> = 0.02). Significant features included preoperative surface area (<i>p</i> = 0.009), Feret diameter (<i>p</i> = 0.0012). In multivariate analysis, only the Feret diameter remained significant (<i>p</i> = 0.01). <b>Conclusions:</b> Postoperative Δ surface area is, among other variables, a strong predictor of 30-day outcomes, while in multivariate analysis, preoperative Feret diameter remains the only independent predictor. Radiomic analysis with 3D Slicer may enhance prognostic accuracy and inform tailored therapeutic strategies. |
| format | Article |
| id | doaj-art-61558b4cbe0445499a7d4fa9a9700671 |
| institution | Kabale University |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Brain Sciences |
| spelling | doaj-art-61558b4cbe0445499a7d4fa9a97006712025-01-24T13:25:50ZengMDPI AGBrain Sciences2076-34252025-01-011515810.3390/brainsci15010058PROMISE: Prognostic Radiomic Outcome Measurement in Acute Subdural Hematoma Evacuation Post-CraniotomyAlexandru Guranda0Antonia Richter1Johannes Wach2Erdem Güresir3Martin Vychopen4Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, GermanyDepartment of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany<b>Background/Objectives:</b> Traumatic acute subdural hematoma (aSDH) often requires surgical intervention, such as craniotomy, to relieve mass lesions and pressure. The extent of hematoma evacuation significantly impacts patient outcomes. This study utilizes 3D Slicer software to analyse post-craniotomy hematoma volume changes and evaluate their prognostic significance in aSDH patients. <b>Methods:</b> Among 178 adult patients diagnosed with aSDH from January 2015 to December 2022, 64 underwent hematoma evacuation via craniotomy. Initial scans were performed within 24 h of trauma, followed by routine postoperative scans to assess residual hematoma. We conducted radiomic analysis of preoperative and postoperative volumes, surface area, Feret diameter, sphericity, flatness, and elongation. Clinical parameters, including SOFA score, APACHE score, pupillary response, comorbidities, age, anticoagulation status, and preoperative haematocrit and haemoglobin levels, were also evaluated. <b>Results:</b> Changes in Δ surface area significantly correlated with 30-day outcomes (<i>p</i> = 0.03) and showed moderate predictive accuracy (AUC = 0.65). Patients with a Δ surface area > 30,090 mm<sup>2</sup> experienced poorer outcomes (OR = 6.66, <i>p</i> = 0.02). Significant features included preoperative surface area (<i>p</i> = 0.009), Feret diameter (<i>p</i> = 0.0012). In multivariate analysis, only the Feret diameter remained significant (<i>p</i> = 0.01). <b>Conclusions:</b> Postoperative Δ surface area is, among other variables, a strong predictor of 30-day outcomes, while in multivariate analysis, preoperative Feret diameter remains the only independent predictor. Radiomic analysis with 3D Slicer may enhance prognostic accuracy and inform tailored therapeutic strategies.https://www.mdpi.com/2076-3425/15/1/58acute subdural hematomasurgical outcomesurface areacraniotomyFeret diameter3D Slicer |
| spellingShingle | Alexandru Guranda Antonia Richter Johannes Wach Erdem Güresir Martin Vychopen PROMISE: Prognostic Radiomic Outcome Measurement in Acute Subdural Hematoma Evacuation Post-Craniotomy Brain Sciences acute subdural hematoma surgical outcome surface area craniotomy Feret diameter 3D Slicer |
| title | PROMISE: Prognostic Radiomic Outcome Measurement in Acute Subdural Hematoma Evacuation Post-Craniotomy |
| title_full | PROMISE: Prognostic Radiomic Outcome Measurement in Acute Subdural Hematoma Evacuation Post-Craniotomy |
| title_fullStr | PROMISE: Prognostic Radiomic Outcome Measurement in Acute Subdural Hematoma Evacuation Post-Craniotomy |
| title_full_unstemmed | PROMISE: Prognostic Radiomic Outcome Measurement in Acute Subdural Hematoma Evacuation Post-Craniotomy |
| title_short | PROMISE: Prognostic Radiomic Outcome Measurement in Acute Subdural Hematoma Evacuation Post-Craniotomy |
| title_sort | promise prognostic radiomic outcome measurement in acute subdural hematoma evacuation post craniotomy |
| topic | acute subdural hematoma surgical outcome surface area craniotomy Feret diameter 3D Slicer |
| url | https://www.mdpi.com/2076-3425/15/1/58 |
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