Acrylamide exposure promotes the progression of depression-like behavior in mice with CUMS via GSDMD-mediated pyroptosis

Acrylamide exposure promotes the progression of depression-like behavior in mice with CUMS via GSDMD-mediated pyroptosis

AIM: We investigated the mechanism by which the environmental toxin acrylamide (AM) promotes depression. Methods: A depression mouse model was constructed using the chronic unpredictable mild stress method, AM was administered orally to simulate the exposure state. Depressive-like behavioral changes...

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Bibliographic Details
Main Authors: JianFeng Liu, Chenyang Han, Jian Shen, Yingcong Lin, Heping Shen, Genghuan Wang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Acrylamide
CUMS
GSDMD
Pyroptosis
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324015197
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