Novel insight and perspectives of nanoparticle-mediated gene delivery and immune-modulating therapies for pancreatic cancer
Abstract Current standard-of-care therapies have failed to improve the survival of patients with metastatic pancreatic cancer (PCA). Therefore, exploring novel therapeutic approaches for cancer targeting is of utmost need. During the past few years, many efforts have been made to develop conventiona...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-024-02975-7 |
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| author | Xinqiao Wang Xue Yin Yuxin Li Shuhui Zhang Meie Hu Minjie Wei Zhenhua Li |
| author_facet | Xinqiao Wang Xue Yin Yuxin Li Shuhui Zhang Meie Hu Minjie Wei Zhenhua Li |
| author_sort | Xinqiao Wang |
| collection | DOAJ |
| description | Abstract Current standard-of-care therapies have failed to improve the survival of patients with metastatic pancreatic cancer (PCA). Therefore, exploring novel therapeutic approaches for cancer targeting is of utmost need. During the past few years, many efforts have been made to develop conventional treatment strategies to reduce chemotherapy resistance. However, critical challenges have impeded current cancer management outcomes, and limited clinical responses have been achieved due to unfavorable off-target effects. Advances in nanotechnology-based gene and immune-modulator delivery systems have excellent advantages for improving the therapeutic efficacy of PCA and provide promising avenues for overcoming the immunosuppressive tumor microenvironment and enhancing patient treatment outcomes. This review article provides insight into the challenges, opportunities, and future perspectives of these novel emerging nanoparticles based on lipid, polymer, and inorganic metal carriers to modulate genes and immunotherapy paradigms for PCA anticancer activity. Graphical Abstract |
| format | Article |
| id | doaj-art-6152eb70bbb14df2aa64901ee9ac8e72 |
| institution | DOAJ |
| issn | 1477-3155 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-6152eb70bbb14df2aa64901ee9ac8e722025-08-20T02:39:41ZengBMCJournal of Nanobiotechnology1477-31552024-12-0122111810.1186/s12951-024-02975-7Novel insight and perspectives of nanoparticle-mediated gene delivery and immune-modulating therapies for pancreatic cancerXinqiao Wang0Xue Yin1Yuxin Li2Shuhui Zhang3Meie Hu4Minjie Wei5Zhenhua Li6School of Pharmacy, China Medical UniversitySchool of Pharmacy, China Medical UniversitySchool of Pharmacy, China Medical UniversitySchool of Pharmacy, China Medical UniversitySchool of Pharmacy, China Medical UniversitySchool of Pharmacy, China Medical UniversitySchool of Pharmacy, China Medical UniversityAbstract Current standard-of-care therapies have failed to improve the survival of patients with metastatic pancreatic cancer (PCA). Therefore, exploring novel therapeutic approaches for cancer targeting is of utmost need. During the past few years, many efforts have been made to develop conventional treatment strategies to reduce chemotherapy resistance. However, critical challenges have impeded current cancer management outcomes, and limited clinical responses have been achieved due to unfavorable off-target effects. Advances in nanotechnology-based gene and immune-modulator delivery systems have excellent advantages for improving the therapeutic efficacy of PCA and provide promising avenues for overcoming the immunosuppressive tumor microenvironment and enhancing patient treatment outcomes. This review article provides insight into the challenges, opportunities, and future perspectives of these novel emerging nanoparticles based on lipid, polymer, and inorganic metal carriers to modulate genes and immunotherapy paradigms for PCA anticancer activity. Graphical Abstracthttps://doi.org/10.1186/s12951-024-02975-7Pancreatic cancerNanoparticlesGene targetingImmunotherapy |
| spellingShingle | Xinqiao Wang Xue Yin Yuxin Li Shuhui Zhang Meie Hu Minjie Wei Zhenhua Li Novel insight and perspectives of nanoparticle-mediated gene delivery and immune-modulating therapies for pancreatic cancer Journal of Nanobiotechnology Pancreatic cancer Nanoparticles Gene targeting Immunotherapy |
| title | Novel insight and perspectives of nanoparticle-mediated gene delivery and immune-modulating therapies for pancreatic cancer |
| title_full | Novel insight and perspectives of nanoparticle-mediated gene delivery and immune-modulating therapies for pancreatic cancer |
| title_fullStr | Novel insight and perspectives of nanoparticle-mediated gene delivery and immune-modulating therapies for pancreatic cancer |
| title_full_unstemmed | Novel insight and perspectives of nanoparticle-mediated gene delivery and immune-modulating therapies for pancreatic cancer |
| title_short | Novel insight and perspectives of nanoparticle-mediated gene delivery and immune-modulating therapies for pancreatic cancer |
| title_sort | novel insight and perspectives of nanoparticle mediated gene delivery and immune modulating therapies for pancreatic cancer |
| topic | Pancreatic cancer Nanoparticles Gene targeting Immunotherapy |
| url | https://doi.org/10.1186/s12951-024-02975-7 |
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