Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules

Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules

Granulomatous pulmonary nodules represent a substantial health threat, with no available targeted therapies. Interventions based on medicinal plants approaches are pivotal for prevention and treatment. Ganoderma lucidum (GL) is a traditional botanical drug to treat inflammatory ailments. The spores...

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Bibliographic Details
Main Authors: Ya Liu, Wendong Xu, Kexin Wang, Zhiye You, Xiaohong Chen, Huihui Ti, Xiaoli Liang, Lin Cao, Hongfei Cai, Juyan Liu, Zifeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
granulomatous pulmonary nodule
G. lucidum spore oil
metabolic balance
inflammatory responses
network analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1612043/full
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