Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25

Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25

Abstract The Mediator complex facilitates interactions between transcription factors and RNA polymerase II, a process that is required for host gene transcription, including in response to viral infections. Among the many subunits in the Mediator complex, the MED25 subunit has been shown to be a tar...

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Main Authors: Parismita Kalita, Oam Khatavkar, Grace Uwase, Yulia Korshunova, Yuying Hu, Nicole D. Wagner, Jian Xu, Jiehong Pan, Jay C. Nix, Michael L. Gross, Steven L. Brody, Dominika Borek, Gaya K. Amarasinghe, Jacqueline E. Payton, Daisy W. Leung
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58216-4
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