Efficacy and safety of puerarin injection as an adjunctive therapy for chronic heart failure: a systematic review and meta-analysis

Efficacy and safety of puerarin injection as an adjunctive therapy for chronic heart failure: a systematic review and meta-analysis

ObjectivePuerarin injection is used for the treatment of chronic heart failure (CHF). The objective of this study is to investigate the efficacy and safety of puerarin injection as an adjunct therapy for CHF through a meta-analysis and systematic review.MethodsWe conducted a comprehensive literature...

Full description

Saved in:

Bibliographic Details
Main Authors:	Hesong Fan, Jingrong Yang, Huaizhe Wang, Shuli Zong, Yiwei Qu, Kefei Wang, Fengyi Zhang, Xiao Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Pharmacology
Subjects:	puerarin injection chronic heart failure meta-analysis systematic review traditional Chinese medicine
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1516059/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations
by: Lokeshvar Ravikumar, et al.
Published: (2025-03-01)

Dual-functional probiotic hydrogel with puerarin integration for microbiota-neuroimmune regulation in antibiotic-free periodontitis therapy
by: Yi Wang, et al.
Published: (2025-11-01)

Research Progress on the Role of Puerarin in the Prevention and Treatment of Alzheimer's Disease
by: Changsong Chu, et al.
Published: (2025-03-01)

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury
by: Jianhong Qi, et al.
Published: (2025-05-01)

Relationship between puerarin and urothelial carcinoembryonic antigen 1 expression in apoptosis and autophagy of esophageal cancer cells
by: LI Jing, WANG Jumei, TIAN Jingrong, BI Lihua, GAO Yuanyuan, SHANG Hong
Published: (2025-01-01)

Effect of Astragalus injection treatment for viral myocarditis: a systematic review and meta-analysis
by: Dinala jialiken, et al.
Published: (2025-01-01)

Puerarin as a Phytochemical Modulator of Gastrointestinal Homeostasis in Livestock: Molecular Mechanisms and Translational Applications
by: Jiehong Zhou, et al.
Published: (2025-06-01)

Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells
by: Xiaoqiang Wang, et al.
Published: (2024-12-01)

Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling
by: Xing Chang, et al.
Published: (2024-09-01)

Puerarin prevents cadmium-induced endoplasmic reticulum stress via SIRT1-dependent PERK-CHOP pathway in HepG2 cells
by: Huang Di, et al.
Published: (2025-04-01)

Effects of Tanreqing injection against ventilator-associated pneumonia: a meta-analysis and systematic review of clinical studies
by: Pochen Li, et al.
Published: (2025-03-01)

Puerarin Targets HIF-1α to Modulate Hypoxia-Related Sphingolipid Metabolism in Diabetic Hepatopathy via the SPTLC2/Ceramide Pathway
by: Mangui Cai, et al.
Published: (2025-03-01)

Puerarin as a multi-targeted modulator of lipid metabolism: molecular mechanisms, therapeutic potential and prospects for nutritional translation
by: Shu Ou, et al.
Published: (2025-07-01)

Dietary Puerarin Enhances Growth, Immune Function, Antioxidant Capacity, and Disease Resistance in Farmed Largemouth Bass, <i>Micropterus salmoides</i>
by: Yi Huang, et al.
Published: (2025-04-01)

Puerarin pretreatment provides protection against myocardial ischemia/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1
by: Yong Yuan, et al.
Published: (2025-01-01)

Daidzein and puerarin synergistically suppress gastric cancer proliferation via STAT3/FAK pathway Inhibition
by: Jun Ge, et al.
Published: (2025-04-01)

Self-Healing Polymeric Puerarin Hydrogel Dressing Promotes Diabetic Wound Healing Through Synergistic Immunomodulation and Tissue-Regenerative Remodeling
by: Shaohui Geng, et al.
Published: (2025-04-01)

Exploration of the Binding Mechanism between Puerarin and β-Lactoglobulin Using Fluorescence Spectroscopy and Molecular Dynamics Simulation
by: MA Bo, LI Rong, XU Ao, DUAN Wenjie, HUANG Yechuan
Published: (2025-04-01)

Efficacy of Shenkang Injection combined with renin-angiotensin-aldosterone system blockers in diabetic nephropathy: a systematic review and meta-analysis of randomized controlled trials
by: Xinyue Zhang, et al.
Published: (2025-12-01)

Green Synthesis of Zinc Oxide Nanoparticles Using Puerarin: Characterization, Antimicrobial Potential, Angiogenesis, and <i>In Ovo</i> Safety Profile Assessment
by: Sergio Liga, et al.
Published: (2024-11-01)

Efficacy and safety of traditional Chinese medicine in the treatment of chronic pulmonary diseases: a systematic review and meta-analysis
by: Shan An, et al.
Published: (2025-05-01)

Puerarin Attenuates the Cytotoxicity Effects of Bisphenol S in HT22 Cells by Regulating the BDNF/TrkB/CREB Signaling Pathway
by: Meilin Qin, et al.
Published: (2025-02-01)

Comparative efficacy and safety of Chinese medicine injections as an adjunctive therapy for cervical cancer in Chinese patients: a network meta-analysis
by: Fei Ma, et al.
Published: (2024-12-01)

Comparative effectiveness of traditional Chinese medicine injections combined with ACEI/ARB for diabetic nephropathy: A systematic review and network meta-analysis
by: Aijing Li, et al.
Published: (2025-07-01)

Puerarin alleviates renal ischemia/reperfusion injury by inhibiting apoptosis and endoplasmic reticulum stress via Nrf2/HO-1 pathway
by: Jingsong Wang, et al.
Published: (2025-02-01)

Synthesis of Ag<sub>2</sub>O/Ag Nanoparticles Using Puerarin: Characterization, Cytotoxicity, <i>In Ovo</i> Safety Profile, Antioxidant, and Antimicrobial Potential Against Nosocomial Pathogens
by: Sergio Liga, et al.
Published: (2025-07-01)

The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis
by: Chongxiang Xue, et al.
Published: (2025-07-01)

Integrative Analyses of Metabolome and Transcriptome Reveal Regulatory Network of Puerarin Biosynthesis in <i>Pueraria montana</i> var. <i>lobata</i>
by: Ting Zhu, et al.
Published: (2024-11-01)

Effect of puerarin administration on serum NOD-like receptor protein 3 (NLRP3) inflammasome, C1Q/TNF-related protein 3 (CTRP3) and lipoprotein-associated phospholipase 2 (LP-PLA2) levels
by: Wang Ge, et al.
Published: (2025-01-01)

Peran Puerarin terhadap Aktivitas Intra dan Ekstraseluler pada Kultur Human Umbilical Vein Endothelial Cells (HUVECs) Pasca Induksi Leptin
by: Mochamad Sasmito Djati, et al.
Published: (2011-02-01)

Explore the mechanism of puerarin to improve diabetic peripheral neuropathy in rats based on AGEs/RAGE signaling pathway
by: HAO Lu, et al.
Published: (2025-05-01)

Efficacy and safety of danshen class injections in the treatment of coronary heart disease: a network meta-analysis
by: Shuang Dai, et al.
Published: (2024-12-01)

Meta-analysis on the efficacy and safety of Guanxin Shutong capsule in the treatment of angina pectoris of coronary heart disease
by: Yaqin Wang, et al.
Published: (2025-06-01)

Puerarin, a key bioactive ingredient of Radix Puerariae, inhibits oxidative stress and protects against homocysteine-induced cardiac injury via PI3K/Akt/Nrf2/HO-1 signaling
by: Shuang Jiang, et al.
Published: (2025-06-01)

The effect of acupuncture on blood glucose control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
by: Yuqi Si, et al.
Published: (2025-06-01)

Efficacy and safety of modified Xuanbai Chengqi Decoction as an adjunctive treatment for severe pneumonia: a systematic review and meta-analysis
by: Yifu Tie, et al.
Published: (2025-04-01)

Yinzhihuang injection as adjuvant treatment for neonatal hyperbilirubinemia: a systematic review and meta-analysis of randomized clinical trials
by: Junqiang Li, et al.
Published: (2024-12-01)

Traditional Chinese medicine as an adjunctive therapy improves cardiac function and reduces serum inflammatory markers in patients with chronic heart failure
by: Zheng Yonghong, et al.
Published: (2025-01-01)

Efficacy and safety of reduning injection for severe pneumonia: a systematic review and meta-analysis
by: Yan Wang, et al.
Published: (2025-08-01)

Shenkang injection in the treatment of diabetic nephropathy at stage Ⅲ: A systematic review and meta-analysis
by: WANG Jing-wen, et al.
Published: (2018-01-01)