DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway

DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway

Abstract Background This study aims to elucidate the effect and mechanism of phospholipid transfer protein (PLTP) on vascular dysfunction in DR and explore the molecular mechanism of abnormal PLTP expression based on DNA methylation. Methods Human retinal microvascular endothelial cells (HRMECs) cul...

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Bibliographic Details
Main Authors: Chunyang Cai, Chufeng Gu, Chunren Meng, Yujie Wang, Qingquan Wei, Shuai He, Dongwei Lai, Xingyun Wang, Tengfei Wang, Qinghua Qiu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Clinical Epigenetics
Subjects:
Phospholipid transfer protein (PLTP)
Diabetic retinopathy (DR)
Vascular dysfunction
DNA methylation
Epigenetics
Online Access:https://doi.org/10.1186/s13148-025-01874-4
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