Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients
BackgroundFerritin is one of the major intracellular iron storage proteins and is implicated in the pathophysiological processes of many inflammatory diseases, but its function in community-acquired pneumonia (CAP) was unclear. The purpose of this study was to evaluate the expression of ferritin and...
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Frontiers Media S.A.
2025-05-01
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| author | Jing Xu Jing Xu Ming-Feng Han Ming-Feng Han Kai-Shu Ma Ting Zhang Ting Zhang Rui-Rui Wang Rui-Rui Wang Jing-Jing Zhang Jing-Jing Zhang Hui Zhao Hui Zhao Lin Fu Lin Fu |
| author_facet | Jing Xu Jing Xu Ming-Feng Han Ming-Feng Han Kai-Shu Ma Ting Zhang Ting Zhang Rui-Rui Wang Rui-Rui Wang Jing-Jing Zhang Jing-Jing Zhang Hui Zhao Hui Zhao Lin Fu Lin Fu |
| author_sort | Jing Xu |
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| description | BackgroundFerritin is one of the major intracellular iron storage proteins and is implicated in the pathophysiological processes of many inflammatory diseases, but its function in community-acquired pneumonia (CAP) was unclear. The purpose of this study was to evaluate the expression of ferritin and analyze the relationship of serum ferritin with CAP.MethodsSevere CAP patients and age- and gender-matched healthy participants were recruited for the study. Serum ferritin was detected through ELISA. Physiological characteristics were recorded.ResultsThe serum ferritin level was significantly increased in severe CAP patients upon initial hospitalization compared to healthy participants, and it decreased after therapy. Correlative analyses hinted that there were obvious relationships of serum ferritin with the indicators of blood routine, liver function, and inflammation. Moreover, linear and logistic regression analyses confirmed that the serum ferritin level was positively related to the scores of CURB-65, CRB-65, and PSI. The poor prognosis including mechanical ventilation, vasoactive agent, ICU admission, death, and longer hospital stays were assessed in severe CAP cases during hospitalization. Multivariate logistic regression showed that higher serum ferritin levels were closely linked to the poor prognostic outcomes.ConclusionThere is significantly positive association between the serum ferritin level upon initial hospitalization with the severity and poor prognosis. Thus, serum ferritin could be an indicator for the determination of severity and prognosis among CAP cases. |
| format | Article |
| id | doaj-art-61371f72b1f3440fb489ffb6efedcb73 |
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| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-61371f72b1f3440fb489ffb6efedcb732025-08-20T02:32:42ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15561851556185Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patientsJing Xu0Jing Xu1Ming-Feng Han2Ming-Feng Han3Kai-Shu Ma4Ting Zhang5Ting Zhang6Rui-Rui Wang7Rui-Rui Wang8Jing-Jing Zhang9Jing-Jing Zhang10Hui Zhao11Hui Zhao12Lin Fu13Lin Fu14Department of Respiratory and Critical Care Medicine, No.2 People’s Hospital of Fuyang City, Fuyang, Anhui, ChinaFuyang Infectious Disease Clinical Collage of Anhui Medical University, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, No.2 People’s Hospital of Fuyang City, Fuyang, Anhui, ChinaFuyang Infectious Disease Clinical Collage of Anhui Medical University, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Funan County People’s Hospital, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, No.2 People’s Hospital of Fuyang City, Fuyang, Anhui, ChinaFuyang Infectious Disease Clinical Collage of Anhui Medical University, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, No.2 People’s Hospital of Fuyang City, Fuyang, Anhui, ChinaFuyang Infectious Disease Clinical Collage of Anhui Medical University, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, No.2 People’s Hospital of Fuyang City, Fuyang, Anhui, ChinaFuyang Infectious Disease Clinical Collage of Anhui Medical University, Fuyang, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaInstitute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaInstitute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaBackgroundFerritin is one of the major intracellular iron storage proteins and is implicated in the pathophysiological processes of many inflammatory diseases, but its function in community-acquired pneumonia (CAP) was unclear. The purpose of this study was to evaluate the expression of ferritin and analyze the relationship of serum ferritin with CAP.MethodsSevere CAP patients and age- and gender-matched healthy participants were recruited for the study. Serum ferritin was detected through ELISA. Physiological characteristics were recorded.ResultsThe serum ferritin level was significantly increased in severe CAP patients upon initial hospitalization compared to healthy participants, and it decreased after therapy. Correlative analyses hinted that there were obvious relationships of serum ferritin with the indicators of blood routine, liver function, and inflammation. Moreover, linear and logistic regression analyses confirmed that the serum ferritin level was positively related to the scores of CURB-65, CRB-65, and PSI. The poor prognosis including mechanical ventilation, vasoactive agent, ICU admission, death, and longer hospital stays were assessed in severe CAP cases during hospitalization. Multivariate logistic regression showed that higher serum ferritin levels were closely linked to the poor prognostic outcomes.ConclusionThere is significantly positive association between the serum ferritin level upon initial hospitalization with the severity and poor prognosis. Thus, serum ferritin could be an indicator for the determination of severity and prognosis among CAP cases.https://www.frontiersin.org/articles/10.3389/fphar.2025.1556185/fullferritincommunity-acquired pneumoniaseverityprognosislongitudinal relationship |
| spellingShingle | Jing Xu Jing Xu Ming-Feng Han Ming-Feng Han Kai-Shu Ma Ting Zhang Ting Zhang Rui-Rui Wang Rui-Rui Wang Jing-Jing Zhang Jing-Jing Zhang Hui Zhao Hui Zhao Lin Fu Lin Fu Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients Frontiers in Pharmacology ferritin community-acquired pneumonia severity prognosis longitudinal relationship |
| title | Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients |
| title_full | Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients |
| title_fullStr | Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients |
| title_full_unstemmed | Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients |
| title_short | Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients |
| title_sort | longitudinal relationships between serum ferritin and prognosis among severe community acquired pneumonia patients |
| topic | ferritin community-acquired pneumonia severity prognosis longitudinal relationship |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1556185/full |
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