Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration
Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this dis...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2014/302568 |
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| author | Salvador Cervin Serrano Dalia González Villareal Maribel Aguilar-Medina Jose Guillermo Romero-Navarro Jose Geovanni Romero Quintana Eliakym Arámbula Meraz Ignacio Osuna Ramírez Veronica Picos-Cárdenas Julio Granados Iris Estrada-García Guzman Sánchez-Schmitz Rosalío Ramos-Payán |
| author_facet | Salvador Cervin Serrano Dalia González Villareal Maribel Aguilar-Medina Jose Guillermo Romero-Navarro Jose Geovanni Romero Quintana Eliakym Arámbula Meraz Ignacio Osuna Ramírez Veronica Picos-Cárdenas Julio Granados Iris Estrada-García Guzman Sánchez-Schmitz Rosalío Ramos-Payán |
| author_sort | Salvador Cervin Serrano |
| collection | DOAJ |
| description | Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this disease has strong genetic determinants. In this study, we explore the possible association between rs1800587 (c.-949C>T) of interleukin-1 alpha (IL1A) and rs2228570 (c.2T>V) and rs731236 (c.1056T>C) of vitamin D receptor (VDR) gene polymorphisms and the development of IDD in northwestern Mexican Mestizo population. Gene polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by age and gender: patients with symptomatic lumbar IDD n=100 and subjects with normal lumbar-spine MRI-scans n=100. Distribution of the mutated alleles in patients and controls was 27.0% versus 28.0% P=0.455 for T of rs1800587 (IL1A); 53.0% versus 58.0% P=0.183 for V of rs2228570 (VDR); and 18.0% versus 21.0% P=0.262 for C of rs731236 (VDR). Our results showed no association between the studied polymorphisms and IDD in this population. This is the first report on the contribution of gene polymorphisms on IDD in a Mexican population. |
| format | Article |
| id | doaj-art-612c139e5477436c90718197998041b1 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-612c139e5477436c90718197998041b12025-02-03T01:07:46ZengWileyInternational Journal of Genomics2314-436X2314-43782014-01-01201410.1155/2014/302568302568Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc DegenerationSalvador Cervin Serrano0Dalia González Villareal1Maribel Aguilar-Medina2Jose Guillermo Romero-Navarro3Jose Geovanni Romero Quintana4Eliakym Arámbula Meraz5Ignacio Osuna Ramírez6Veronica Picos-Cárdenas7Julio Granados8Iris Estrada-García9Guzman Sánchez-Schmitz10Rosalío Ramos-Payán11Division of Pain, ISSSTE Hospital, 80200 Culiacán, SIN, MexicoFaculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, MexicoFaculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, MexicoFaculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, MexicoFaculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, MexicoFaculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, MexicoFaculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, MexicoHuman Genetics Laboratory of the Research Unit, Faculty of Medicine, Autonomous University of Sinaloa, 80019 Culiacán, SIN, MexicoDivision of Immunogenetics, National Institute of Medical Sciences and Nutrition, 14000 Mexico City, DF, MexicoDepartment of Immunology, National School of Biological Science, National Polytechnic Institute, 11340 Mexico City, DF, MexicoDivision of Infectious Diseases, Boston Children’s Hospital and Harvard Medical School, Harvard University, Boston, MA 02115, USAFaculty of Biological and Chemical Sciences, Doctoral Programs in Biotechnology and Biomedical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, MexicoIntervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this disease has strong genetic determinants. In this study, we explore the possible association between rs1800587 (c.-949C>T) of interleukin-1 alpha (IL1A) and rs2228570 (c.2T>V) and rs731236 (c.1056T>C) of vitamin D receptor (VDR) gene polymorphisms and the development of IDD in northwestern Mexican Mestizo population. Gene polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by age and gender: patients with symptomatic lumbar IDD n=100 and subjects with normal lumbar-spine MRI-scans n=100. Distribution of the mutated alleles in patients and controls was 27.0% versus 28.0% P=0.455 for T of rs1800587 (IL1A); 53.0% versus 58.0% P=0.183 for V of rs2228570 (VDR); and 18.0% versus 21.0% P=0.262 for C of rs731236 (VDR). Our results showed no association between the studied polymorphisms and IDD in this population. This is the first report on the contribution of gene polymorphisms on IDD in a Mexican population.http://dx.doi.org/10.1155/2014/302568 |
| spellingShingle | Salvador Cervin Serrano Dalia González Villareal Maribel Aguilar-Medina Jose Guillermo Romero-Navarro Jose Geovanni Romero Quintana Eliakym Arámbula Meraz Ignacio Osuna Ramírez Veronica Picos-Cárdenas Julio Granados Iris Estrada-García Guzman Sánchez-Schmitz Rosalío Ramos-Payán Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration International Journal of Genomics |
| title | Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration |
| title_full | Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration |
| title_fullStr | Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration |
| title_full_unstemmed | Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration |
| title_short | Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration |
| title_sort | genetic polymorphisms of interleukin 1 alpha and the vitamin d receptor in mexican mestizo patients with intervertebral disc degeneration |
| url | http://dx.doi.org/10.1155/2014/302568 |
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