Evolutionary Analysis of Mammalian ACE2 and the Key Residues Involved in Binding to the Spike Protein Revealed Potential SARS-CoV-2 Hosts

Evolutionary Analysis of Mammalian ACE2 and the Key Residues Involved in Binding to the Spike Protein Revealed Potential SARS-CoV-2 Hosts

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) spilled over to humans via wild mammals, entering the host cell using angiotensin-converting enzyme 2 (ACE2) as receptor through Spike (S) protein binding. While SARS-CoV-2 became fully adapted to humans and globally spr...

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Bibliographic Details
Main Authors: Luciano Rodrigo Lopes1, Natália Carvalho de Lucca Pina1, Antonio Carlos da Silva Junior1, Paulo- Bandiera Paiva1
Format: Article
Language:English
Published: Pasteur Institute of Iran 2022-03-01
Series:Journal of Medical Microbiology and Infectious Diseases
Subjects:
sars-cov-2
coronavirus
ace2
mammals
wildlife
Online Access:https://jommid.pasteur.ac.ir/article-1-436-en.html
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