Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers
In order to fill the gap in previous research, we aim to investigate the relationship between single and co-exposure to bisphenols (BPs) and per- and polyfluoroalkyl substances (PFAS) and behavioral problems among Chinese preschoolers. The current study measured urinary BPs and PFAS concentrations i...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325008930 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849390855754874880 |
|---|---|
| author | Ruo-yu Li Jun Wu Wan Xiao Yang Zhou Ke Liang Jia-ying Bao Zhi-yuan Yao Chao Zhang Yu-hui Wan |
| author_facet | Ruo-yu Li Jun Wu Wan Xiao Yang Zhou Ke Liang Jia-ying Bao Zhi-yuan Yao Chao Zhang Yu-hui Wan |
| author_sort | Ruo-yu Li |
| collection | DOAJ |
| description | In order to fill the gap in previous research, we aim to investigate the relationship between single and co-exposure to bisphenols (BPs) and per- and polyfluoroalkyl substances (PFAS) and behavioral problems among Chinese preschoolers. The current study measured urinary BPs and PFAS concentrations in 823 Chinese preschoolers. The children’s behavioral problems were assessed using the Conners’ Parent Symptom Questionnaire (PSQ). Binary logistic regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were used to examine the association between single or co-exposure to all chemicals and behavioral problems among preschoolers. After controlling for covariates, binary logistic regression results showed that bisphenol AP (BPAP), bisphenol B (BPB), bisphenol S (BPS), perfluorobutanesulfonic acid (PFBS), perfluorohexanesulfonic acid (PFHxS), and perfluorooctane sulphonate (PFOS) were significantly associated with children’s behavioral problems (OR = 1.89–2.60, 95 % CI: 1.01–5.21). The WQS index was significantly positively associated with behavioral problems (OR = 2.01, 95 % CI: 1.24–3.32). BPAP and PFHxS were the chemicals with the most significant weights. BKMR results also found that the mixture of BPs and PFAS had a partially significant positive association with preschoolers’ behavioral problems. This study indicated that a mixture of urinary BPs and PFAS has a combined effect on behavioral problems in preschoolers. In addition, BPAP and PFHxS, which are common substitutes for BPA and PFOS respectively, have a greater impact on preschoolers’ behavioral problems and are worthy of further attention. |
| format | Article |
| id | doaj-art-612a76e2d7624f14b38c387daf55683d |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-612a76e2d7624f14b38c387daf55683d2025-08-20T03:41:17ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130211854810.1016/j.ecoenv.2025.118548Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolersRuo-yu Li0Jun Wu1Wan Xiao2Yang Zhou3Ke Liang4Jia-ying Bao5Zhi-yuan Yao6Chao Zhang7Yu-hui Wan8Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Anhui, China; Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Anhui, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Anhui, China; Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Anhui, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Anhui, China; Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Anhui, ChinaDepartment of Health Promotion and Behavioural Sciences, School of Public Health, Anhui Medical University, Anhui, ChinaDepartment of Health Promotion and Behavioural Sciences, School of Public Health, Anhui Medical University, Anhui, ChinaDepartment of Health Promotion and Behavioural Sciences, School of Public Health, Anhui Medical University, Anhui, ChinaDepartment of Hygiene Inspection and Quarantine, School of Public Health, Anhui Medical University, Anhui, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Anhui, China; Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Anhui, China; Department of Health Promotion and Behavioural Sciences, School of Public Health, Anhui Medical University, Anhui, China; Correspondence to: Department of Health Promotion and Behavioural Sciences, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Anhui, China; Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course, Anhui Medical University, Anhui, China; Department of Health Promotion and Behavioural Sciences, School of Public Health, Anhui Medical University, Anhui, China; Correspondence to: Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.In order to fill the gap in previous research, we aim to investigate the relationship between single and co-exposure to bisphenols (BPs) and per- and polyfluoroalkyl substances (PFAS) and behavioral problems among Chinese preschoolers. The current study measured urinary BPs and PFAS concentrations in 823 Chinese preschoolers. The children’s behavioral problems were assessed using the Conners’ Parent Symptom Questionnaire (PSQ). Binary logistic regression, weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR) were used to examine the association between single or co-exposure to all chemicals and behavioral problems among preschoolers. After controlling for covariates, binary logistic regression results showed that bisphenol AP (BPAP), bisphenol B (BPB), bisphenol S (BPS), perfluorobutanesulfonic acid (PFBS), perfluorohexanesulfonic acid (PFHxS), and perfluorooctane sulphonate (PFOS) were significantly associated with children’s behavioral problems (OR = 1.89–2.60, 95 % CI: 1.01–5.21). The WQS index was significantly positively associated with behavioral problems (OR = 2.01, 95 % CI: 1.24–3.32). BPAP and PFHxS were the chemicals with the most significant weights. BKMR results also found that the mixture of BPs and PFAS had a partially significant positive association with preschoolers’ behavioral problems. This study indicated that a mixture of urinary BPs and PFAS has a combined effect on behavioral problems in preschoolers. In addition, BPAP and PFHxS, which are common substitutes for BPA and PFOS respectively, have a greater impact on preschoolers’ behavioral problems and are worthy of further attention.http://www.sciencedirect.com/science/article/pii/S0147651325008930BisphenolsPer- and polyfluoroalkyl substancesPreschoolersBehavioral problems |
| spellingShingle | Ruo-yu Li Jun Wu Wan Xiao Yang Zhou Ke Liang Jia-ying Bao Zhi-yuan Yao Chao Zhang Yu-hui Wan Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers Ecotoxicology and Environmental Safety Bisphenols Per- and polyfluoroalkyl substances Preschoolers Behavioral problems |
| title | Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers |
| title_full | Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers |
| title_fullStr | Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers |
| title_full_unstemmed | Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers |
| title_short | Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers |
| title_sort | association between exposure to bisphenols and per and polyfluoroalkyl substances and behavioral problems among chinese preschoolers |
| topic | Bisphenols Per- and polyfluoroalkyl substances Preschoolers Behavioral problems |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325008930 |
| work_keys_str_mv | AT ruoyuli associationbetweenexposuretobisphenolsandperandpolyfluoroalkylsubstancesandbehavioralproblemsamongchinesepreschoolers AT junwu associationbetweenexposuretobisphenolsandperandpolyfluoroalkylsubstancesandbehavioralproblemsamongchinesepreschoolers AT wanxiao associationbetweenexposuretobisphenolsandperandpolyfluoroalkylsubstancesandbehavioralproblemsamongchinesepreschoolers AT yangzhou associationbetweenexposuretobisphenolsandperandpolyfluoroalkylsubstancesandbehavioralproblemsamongchinesepreschoolers AT keliang associationbetweenexposuretobisphenolsandperandpolyfluoroalkylsubstancesandbehavioralproblemsamongchinesepreschoolers AT jiayingbao associationbetweenexposuretobisphenolsandperandpolyfluoroalkylsubstancesandbehavioralproblemsamongchinesepreschoolers AT zhiyuanyao associationbetweenexposuretobisphenolsandperandpolyfluoroalkylsubstancesandbehavioralproblemsamongchinesepreschoolers AT chaozhang associationbetweenexposuretobisphenolsandperandpolyfluoroalkylsubstancesandbehavioralproblemsamongchinesepreschoolers AT yuhuiwan associationbetweenexposuretobisphenolsandperandpolyfluoroalkylsubstancesandbehavioralproblemsamongchinesepreschoolers |