Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemia

Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemia

Chimeric antigen receptor-modified T (CAR-T) cell therapy, as a new type of cellular immunotherapy, has shown good clinical efficacy in the treatment of malignant hematological tumors, especially B-cell acute lymphoblastic leukemia. However, there are problems such as antigen loss and immune evasion...

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Bibliographic Details
Main Author:	CAO Jinjin, DU Juan, QU Shanna, ZHU Mingyu, WANG Yang, HU Han, LIU Binlei
Format:	Article
Language:	zho
Published:	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2025-05-01
Series:	Jichu yixue yu linchuang
Subjects:	multi-target\|car-t cell therapy\|b-cell acute lymphoblastic leukemia\|off-target effect\|tumor-associated antigen
Online Access:	https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-5-675.pdf
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