Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemia
Chimeric antigen receptor-modified T (CAR-T) cell therapy, as a new type of cellular immunotherapy, has shown good clinical efficacy in the treatment of malignant hematological tumors, especially B-cell acute lymphoblastic leukemia. However, there are problems such as antigen loss and immune evasion...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2025-05-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-5-675.pdf |
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| author | CAO Jinjin, DU Juan, QU Shanna, ZHU Mingyu, WANG Yang, HU Han, LIU Binlei |
| author_facet | CAO Jinjin, DU Juan, QU Shanna, ZHU Mingyu, WANG Yang, HU Han, LIU Binlei |
| author_sort | CAO Jinjin, DU Juan, QU Shanna, ZHU Mingyu, WANG Yang, HU Han, LIU Binlei |
| collection | DOAJ |
| description | Chimeric antigen receptor-modified T (CAR-T) cell therapy, as a new type of cellular immunotherapy, has shown good clinical efficacy in the treatment of malignant hematological tumors, especially B-cell acute lymphoblastic leukemia. However, there are problems such as antigen loss and immune evasion in single-target selection, so multi-target therapy strategies are gradually gaining attention. Multi-target CAR-T can effectively avoid antigen escape caused by a single target by targeting multiple tumor-associated antigens at the same time, reduce the risk of recurrence, and is expected to improve the therapeutic effect. This paper primarily discusses the structural types of multi-target CAR-T cell therapy and its clinical trial applications in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), aiming to provide future references for the treatment of B-ALL. |
| format | Article |
| id | doaj-art-6129a929916e4100a0e719ffe07eaa09 |
| institution | Kabale University |
| issn | 1001-6325 |
| language | zho |
| publishDate | 2025-05-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj-art-6129a929916e4100a0e719ffe07eaa092025-08-20T03:28:26ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252025-05-0145567568010.16352/j.issn.1001-6325.2025.05.0675Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemiaCAO Jinjin, DU Juan, QU Shanna, ZHU Mingyu, WANG Yang, HU Han, LIU Binlei01. School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068;;2. Wuhan Binhui Biopharmaceutical Co. , Ltd. , Wuhan 436030, ChinaChimeric antigen receptor-modified T (CAR-T) cell therapy, as a new type of cellular immunotherapy, has shown good clinical efficacy in the treatment of malignant hematological tumors, especially B-cell acute lymphoblastic leukemia. However, there are problems such as antigen loss and immune evasion in single-target selection, so multi-target therapy strategies are gradually gaining attention. Multi-target CAR-T can effectively avoid antigen escape caused by a single target by targeting multiple tumor-associated antigens at the same time, reduce the risk of recurrence, and is expected to improve the therapeutic effect. This paper primarily discusses the structural types of multi-target CAR-T cell therapy and its clinical trial applications in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), aiming to provide future references for the treatment of B-ALL.https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-5-675.pdfmulti-target|car-t cell therapy|b-cell acute lymphoblastic leukemia|off-target effect|tumor-associated antigen |
| spellingShingle | CAO Jinjin, DU Juan, QU Shanna, ZHU Mingyu, WANG Yang, HU Han, LIU Binlei Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemia Jichu yixue yu linchuang multi-target|car-t cell therapy|b-cell acute lymphoblastic leukemia|off-target effect|tumor-associated antigen |
| title | Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemia |
| title_full | Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemia |
| title_fullStr | Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemia |
| title_full_unstemmed | Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemia |
| title_short | Application of multi-targeted CAR-T cell therapy in B-cell acute lymphoblastic leukemia |
| title_sort | application of multi targeted car t cell therapy in b cell acute lymphoblastic leukemia |
| topic | multi-target|car-t cell therapy|b-cell acute lymphoblastic leukemia|off-target effect|tumor-associated antigen |
| url | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-5-675.pdf |
| work_keys_str_mv | AT caojinjindujuanqushannazhumingyuwangyanghuhanliubinlei applicationofmultitargetedcartcelltherapyinbcellacutelymphoblasticleukemia |