Progress of Clinical Research on Trop2 in Solid Tumors
Trophoblast cell surface antigen 2 (Trop2) is a glycoprotein that is barely expressed in normal tissues but highly expressed in malignant tumors; it is remarkably associated with poor prognosis. Various targeted therapeutics against Trop2, such as anti-Trop2 antibodies and antibody-drug conjugate dr...
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| Format: | Article |
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Magazine House of Cancer Research on Prevention and Treatment
2025-01-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0542 |
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| author | Ying ZHANG Yueping LIU |
| author_facet | Ying ZHANG Yueping LIU |
| author_sort | Ying ZHANG |
| collection | DOAJ |
| description | Trophoblast cell surface antigen 2 (Trop2) is a glycoprotein that is barely expressed in normal tissues but highly expressed in malignant tumors; it is remarkably associated with poor prognosis. Various targeted therapeutics against Trop2, such as anti-Trop2 antibodies and antibody-drug conjugate drugs targeting Trop2, have been developed, and some therapeutics have been approved or are in clinical trials for cancer treatment. In this review, we comprehensively discuss the gene structure, mechanism of action, clinical research, drug development, and other aspects of Trop2 to provide references for the clinical development of effective and safe Trop2-targeting drugs. |
| format | Article |
| id | doaj-art-612484507232489f899c60c8e3ba2687 |
| institution | Kabale University |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-612484507232489f899c60c8e3ba26872025-01-23T07:44:49ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-01-01521798610.3971/j.issn.1000-8578.2025.24.054220240542Progress of Clinical Research on Trop2 in Solid TumorsYing ZHANG0Yueping LIU1Department of Pathology, The Fourth Hospital of Hebei Medical University/Hebei Cancer Hospital, Shijiazhuang 050011, ChinaDepartment of Pathology, The Fourth Hospital of Hebei Medical University/Hebei Cancer Hospital, Shijiazhuang 050011, ChinaTrophoblast cell surface antigen 2 (Trop2) is a glycoprotein that is barely expressed in normal tissues but highly expressed in malignant tumors; it is remarkably associated with poor prognosis. Various targeted therapeutics against Trop2, such as anti-Trop2 antibodies and antibody-drug conjugate drugs targeting Trop2, have been developed, and some therapeutics have been approved or are in clinical trials for cancer treatment. In this review, we comprehensively discuss the gene structure, mechanism of action, clinical research, drug development, and other aspects of Trop2 to provide references for the clinical development of effective and safe Trop2-targeting drugs.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0542trop2cancermechanismstructuretargeted therapy |
| spellingShingle | Ying ZHANG Yueping LIU Progress of Clinical Research on Trop2 in Solid Tumors Zhongliu Fangzhi Yanjiu trop2 cancer mechanism structure targeted therapy |
| title | Progress of Clinical Research on Trop2 in Solid Tumors |
| title_full | Progress of Clinical Research on Trop2 in Solid Tumors |
| title_fullStr | Progress of Clinical Research on Trop2 in Solid Tumors |
| title_full_unstemmed | Progress of Clinical Research on Trop2 in Solid Tumors |
| title_short | Progress of Clinical Research on Trop2 in Solid Tumors |
| title_sort | progress of clinical research on trop2 in solid tumors |
| topic | trop2 cancer mechanism structure targeted therapy |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0542 |
| work_keys_str_mv | AT yingzhang progressofclinicalresearchontrop2insolidtumors AT yuepingliu progressofclinicalresearchontrop2insolidtumors |