A novel UHPLC-HRMS method for simultaneous determination of 20 amino metabolites and proteins in lymphoma patients’ cells and serum

A novel UHPLC-HRMS method for simultaneous determination of 20 amino metabolites and proteins in lymphoma patients’ cells and serum

Abstract Highly sensitive and selective monitoring of amino metabolites such as glutamine, arginine, tryptophan and related proteins played significant roles in early diagnosis and warning of lymphoma. But those limited abundance and lacked chromophore group in vivo were bottleneck of multivariate a...

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Bibliographic Details
Main Authors: Mei Zhang, Qingkun Ma, Han Zhao, Ge Sun, Tenghua Zhao, Yuqing Wang, Shiji Chen, Lele Jia, Yixiang Song, Yanling Mu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Aminos metabolites
Proteins
Lymphoma
Machine learning
3-BMP
UHPLC-HRMS
Online Access:https://doi.org/10.1038/s41598-025-04645-6
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